Sotalol and Dasatinib: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Dasatinib
Sotalol
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
An increased risk of QT interval prolongation
Interaction Deep Dive
Avoid use of sotalol, a QT interval prolonging agent, with other drugs that are known to prolong the QT interval12. There have been isolated reports of QTc prolongation and torsade de pointes temporally related to the concomitant administration of sotalol with the QT prolonging agent ciprofloxacin 43.
Why it happens (mechanism)
Additive QT interval prolongation
Literature reports
2 reports — tap to read
a) A 70-year-old female receiving sotalol therapy experienced torsade de pointes following coadministration of the QT prolonging agent ciprofloxacin. The patient was admitted with new onset atrial fibrillation with rapid ventricular response and was given IV amiodarone (loading dose, 450 mg; followed by 24-hour infusion, 650 mg) and digoxin (0.25 mg/day). The patient converted to sinus rhythm within 48 hours of admission. Both amiodarone and digoxin were discontinued and sotalol (40 mg twice daily) was initiated. The next day the patient presented with jaundice, fever, and cholecystitis, and was treated with IV ciprofloxacin 400 mg twice daily. Within 12 hours of ciprofloxacin administration, the patient developed syncope with documented torsade de pointes that necessitated defibrillation. Her QTc interval, which was 0.38 seconds prior to ciprofloxacin initiation, was significantly (0.62 seconds) increased following resuscitation. Within 3 days of ciprofloxacin and sotalol discontinuation, the QTc interval decreased to 0.42 seconds 3.
b) Torsade de pointes temporally related to the QT prolonging agent ciprofloxacin administration was reported in a 44-year-old female who was stable on sotalol 160 mg twice a day for the treatment of supraventricular arrhythmia. Pyelonephritis was treated with ciprofloxacin 1 g in the emergency room (ER). At that time, the QTc interval measured 405 milliseconds. The patient was discharged on ciprofloxacin 500 mg twice a day. Within hours of discharge, she experienced several presyncopal and syncopal episodes and returned to the ER. Torsade-induced syncope was diagnosed and defibrillation was required. The QTc interval following resuscitation was 590 milliseconds which was compared with previous normal or slightly increased intervals (maximum, 460 milliseconds) during sotalol maintenance therapy. Upon discontinuation of both medications, the QTc interval normalized within 2 days 4.
Common questions
Can I take Sotalol and Dasatinib together?
An increased risk of QT interval prolongation Always confirm with your pharmacist or prescriber before making any change.
How serious is the Sotalol and Dasatinib interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "rapid". Effects can appear quickly, often within about 24 hours of combining the drugs.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Sotalol or Dasatinib need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (4)
- Product Information: BETAPACE(R) oral tablets, sotalol HCl oral tablets. Covis Pharma (per FDA), King of Prussia, PA, 2021. DailyMed
- Product Information: BETAPACE(R) AF oral tablets, sotalol HCl oral tablets. Covis Pharma (per FDA), King of Prussia, PA, 2021. DailyMed
- Keivanidou ANASTASIA, Arnaoutoglou CHRISTOS, Krommydas ARGYRIOS, et al: Ciprofloxacin induced acquired long QT syndrome in a patient under class III antiarrhythmic therapy. Cardiology journal 2009; 16(2):172-174.
- Prabhakar M & Krahn AD: Ciprofloxacin-induced acquired long QT syndrome. Heart Rhythm 2004; 1(5):624-626. PubMed
Keep reading about Dasatinib
Keep reading about Sotalol
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
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