Sotalol

124 interactions 6 explained in plain English

Also sold as: Betapace Betapace® Betapace® AF Sorine Sorine® Sotylize

About Sotalol

Sotalol is used to treat irregular heartbeats. Sotalol is in a class of medications called antiarrhythmics. It works by acting on the heart muscle to improve the heart's rhythm. Read the full Sotalol drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Felbamate Sertraline Eribulin Injection Levofloxacin Injection Indacaterol Oral Inhalation Dasatinib

75 Major 49 Moderate

All (124) Major (75) Moderate (49)

Major

Sotalol Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Sotalol Granisetron Injection Granisol An increased risk of QT interval prolongation Details Sotalol Histrelin Implant Supprelin An increased risk of QT interval prolongation Details Sotalol Hydroxychloroquine Plaquenil An increased risk of QT interval prolongation Details Sotalol Indacaterol Oral Inhalation Arcapta® Decreased efficacy of indacaterol Details Sotalol Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Sotalol Isoetharine Oral Inhalation Beta-2® Decreased efficacy of beta-2 agonist Details Sotalol Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Sotalol Ivabradine Corlanor An increased risk of QT interval prolongation Details Sotalol Ketoconazole Topical Extina® Foam An increased risk of QT interval prolongation Details Sotalol Lacosamide Injection Motpoly An increased risk of AV block, bradycardia, and ventricular tachyarrhythmia Details Sotalol Lefamulin Xenleta Increased risk of QT interval prolongation Details Sotalol Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Sotalol Levofloxacin Levaquin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Sotalol Levofloxacin Injection Levaquin An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Sotalol Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Sotalol Mefloquine Lariam® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Sotalol Metaproterenol Alupent® Decreased efficacy of beta-2 agonist Details Sotalol Methylergonovine Methergine An increased risk of enhanced vasoconstrictive Details Sotalol Metronidazole Flagyl An increased risk of QT interval prolongation Details Sotalol Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Sotalol Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Sotalol Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Sotalol Mexiletine Mexitil® Increased risk of QT interval prolongation or prolonged refractoriness Details Sotalol Moxifloxacin Avelox Increased risk of QT interval prolongation Details Sotalol Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Sotalol Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Sotalol Nafarelin Nasal Spray Synarel An increased risk of QT interval prolongation Details Sotalol Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Sotalol Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Sotalol Ofloxacin Floxin® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Sotalol Ofloxacin Ophthalmic Ocuflox An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Sotalol Ofloxacin Otic Floxin® Otic An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Sotalol Olodaterol Oral Inhalation Striverdi Reduced olodaterol exposure and reduced sotalol exposure and an increased risk of QT interval prolongation and ventricular arrhyth... Details Sotalol Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.