Sotalol

Name: Sotalol Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

124 interactions 6 explained in plain English

Also sold as: Betapace Betapace® Betapace® AF Sorine Sorine® Sotylize

About Sotalol

Sotalol is used to treat irregular heartbeats. Sotalol is in a class of medications called antiarrhythmics. It works by acting on the heart muscle to improve the heart's rhythm. Read the full Sotalol drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Felbamate Sertraline Eribulin Injection Levofloxacin Injection Indacaterol Oral Inhalation Dasatinib

75 Major 49 Moderate

All (124) Major (75) Moderate (49)

Moderate

Sotalol Meloxicam Injection Alloxate Reduced antihypertensive effect Details Sotalol Metformin Fortamet® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sotalol Methimazole Felanorm Altered metabolism of the beta-adrenergic blocker Details Sotalol Methyldopa Aldomet® Exaggerated hypertensive response, tachycardia, or arrhythmias during physical stress or exposure to exogenous catecholamines Details Sotalol Miglitol Glyset® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sotalol Nabumetone Relafen Reduced antihypertensive effect Details Sotalol Naproxen Aleve Reduced antihypertensive effect Details Sotalol Nateglinide Starlix® Hypoglycemia or hyperglycemia; decreased symptoms of hypoglycemia Details Sotalol Nifedipine Adalat® An increased risk of congestive heart failure, severe hypotension or exacerbation of angina Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.