Sparfloxacin

92 interactions 5 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Felbamate Sertraline Oxaliplatin Injection Eribulin Injection Dasatinib Levofloxacin Injection

63 Contraindicated 28 Major 1 Moderate

All (92) Contraindicated (63) Major (28) Moderate (1)

Contraindicated

Sparfloxacin Ivabradine Corlanor An increased risk of QT interval prolongation Details Sparfloxacin Ketoconazole Topical Extina® Foam An increased risk of QT interval prolongation Details Sparfloxacin Lefamulin Xenleta An increased risk of QT interval prolongation Details Sparfloxacin Lenvatinib Lenvima An increased risk of QT interval prolongation Details Sparfloxacin Levofloxacin Levaquin An increased risk of QT interval prolongation Details Sparfloxacin Levofloxacin Injection Levaquin An increased risk of QT interval prolongation Details Sparfloxacin Loperamide Diamode An increased risk of QT interval prolongation Details Sparfloxacin Mefloquine Lariam® An increased risk of QT interval prolongation Details Sparfloxacin Metronidazole Flagyl An increased risk of QT interval prolongation Details Sparfloxacin Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Sparfloxacin Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Sparfloxacin Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Sparfloxacin Moxifloxacin Avelox An increased risk of QT interval prolongation Details Sparfloxacin Moxifloxacin Injection Avelox An increased risk of QT interval prolongation Details Sparfloxacin Moxifloxacin Ophthalmic Moxeza® An increased risk of QT interval prolongation Details Sparfloxacin Nafarelin Nasal Spray Synarel An increased risk of QT interval prolongation Details Sparfloxacin Octreotide Bynfezia An increased risk of QT interval prolongation Details Sparfloxacin Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Sparfloxacin Ofloxacin Floxin® An increased risk of QT interval prolongation Details Sparfloxacin Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Sparfloxacin Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Sparfloxacin Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation Details Sparfloxacin Oxaliplatin Injection Eloxatin® An increased risk of QT interval prolongation Details

Major

Sparfloxacin Acarbose Prandase® Explained Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sparfloxacin Alogliptin Nesina Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sparfloxacin Budesonide Entocort An increased risk of tendon rupture Details Sparfloxacin Budesonide Nasal Spray Rhinocort An increased risk of tendon rupture Details Sparfloxacin Budesonide Oral Inhalation Pulmicort An increased risk of tendon rupture Details Sparfloxacin Canagliflozin Invokana Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sparfloxacin Dapagliflozin Farxiga Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sparfloxacin Deflazacort Emflaza An increased risk of tendon rupture Details Sparfloxacin Dexamethasone Injection Decadron An increased risk of tendon rupture Details Sparfloxacin Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) An increased risk of tendon rupture Details Sparfloxacin Dulaglutide Injection Trulicity Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sparfloxacin Empagliflozin Glyxambi® (as a combination product containing Empagliflozin and Linagliptin) Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sparfloxacin Ertugliflozin Steglatro Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sparfloxacin Exenatide Injection Bydureon Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sparfloxacin Fludrocortisone Acetate Florinef® An increased risk of tendon rupture Details Sparfloxacin Glimepiride Amaryl Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sparfloxacin Glipizide Glucotrol Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.