Sparfloxacin

92 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Felbamate Sertraline Oxaliplatin Injection Eribulin Injection Dasatinib Levofloxacin Injection
63 Contraindicated 28 Major 1 Moderate
All (92) Contraindicated (63) Major (28) Moderate (1)

Major

Sparfloxacin Hydrocortisone Ala-Cort An increased risk of tendon rupture Details Sparfloxacin Hydrocortisone Injection A-Hydrocort® An increased risk of tendon rupture Details Sparfloxacin Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sparfloxacin Insulin Detemir (Rdna Origin) Injection Levemir Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sparfloxacin Insulin Glulisine (Rdna Origin) Injection Apidra Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sparfloxacin Linagliptin Tradjenta Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sparfloxacin Liraglutide Injection Saxenda Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sparfloxacin Lixisenatide Injection Adlyxin® Changes in blood glucose with an increased risk of hypoglycemia or hyperglycemia and delayed therapeutic effect of antibiotic Details Sparfloxacin Metformin Fortamet® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sparfloxacin Miglitol Glyset® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Sparfloxacin Nateglinide Starlix® Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details

Moderate

Sparfloxacin Lanthanum Fosrenol® Reduced bioavailability of quinolone antibiotics Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.