Spironolactone
71 interactions 5 explained in plain English
Also sold as:
Aldactone
Carospir
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Colchicine
Bromfenac Ophthalmic
Perindopril
Enoxaparin Injection
Aspirin
Arsenic Trioxide
Contraindicated
Spironolactone Colchicine Colcrys Explained Increased colchicine exposure and an increased risk of colchicine toxicity DetailsMajor
Spironolactone Acetaminophen And Codeine Capital® & Codeine Explained Reduced diuretic efficacy Details Spironolactone Lisinopril Prinivil Explained Increased risk of hyperkalemia Details Spironolactone Buprenorphine Belbuca Explained Reduced efficacy of diuretics Details Spironolactone Relugolix Orgovyx Explained Increased relugolix exposure Details Spironolactone Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Spironolactone Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Spironolactone Aspirin Acuprin® Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Aspirin Rectal Aspirin Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Benazepril Lotensin Increased risk of hyperkalemia Details Spironolactone Abiraterone Abirtega Increased PSA levels Details Spironolactone Azilsartan Edarbi An increased risk of hyperkalemia, an increased risk of hypotension and an increased risk of worsening of renal function Details Spironolactone Bromfenac Ophthalmic Bromday® Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Captopril Capoten® Increased risk of hyperkalemia Details Spironolactone Cefepime Injection Maxipime® An increased risk of nephrotoxicity Details Spironolactone Cyclosporine Injection Atopica An increased risk of hyperkalemia and an increased cycloSPORINE exposure Details Spironolactone Cyclosporine Ophthalmic Cequa An increased risk of hyperkalemia and an increased cycloSPORINE exposure Details Spironolactone Dabigatran Pradaxa® Increased dabigatran exposure and an increased risk of bleeding Details Spironolactone Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Spironolactone Dalteparin Injection Fragmin Increased risk of hyperkalemia Details Spironolactone Diclofenac Ophthalmic Voltaren® Eye Drops Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Diclofenac Topical (Actinic Keratosis) Pennsaid Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Diclofenac Topical (Arthritis Pain) Pennsaid® Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Diclofenac Transdermal Patch Flector Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Digoxin Cardoxin® Increased digoxin exposure Details Spironolactone Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Spironolactone Enalapril Epaned Increased risk of hyperkalemia Details Spironolactone Enoxaparin Lovenox Increased risk of hyperkalemia Details Spironolactone Enoxaparin Injection Lovenox Increased risk of hyperkalemia Details Spironolactone Eprosartan Teveten® An increased risk of hyperkalemia, an increased risk of hypotension and an increased risk of worsening of renal function Details Spironolactone Etodolac Lodine Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Fenoprofen Fenopron Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Fentanyl Transdermal Patch Duragesic® Reduced diuretic efficacy Details Spironolactone Finerenone Kerendia Increased risk of hyperkalemia Details Spironolactone Flurbiprofen Ansaid Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Flurbiprofen Ophthalmic Ocufen Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Fosinopril Monopril® Increased risk of hyperkalemia Details Spironolactone Heparin Increased risk of hyperkalemia Details Spironolactone Heparin Injection Lipo-Hepin® Increased risk of hyperkalemia Details Spironolactone Hydromorphone Injection Dilaudid Reduced efficacy of diuretics DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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