Spironolactone
71 interactions 5 explained in plain English
Also sold as:
Aldactone
Carospir
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Colchicine
Bromfenac Ophthalmic
Perindopril
Enoxaparin Injection
Aspirin
Arsenic Trioxide
Moderate
Spironolactone Aliskiren Tekturna Hyperkalemia Details Spironolactone Amikacin Injection Amikin® An increased risk of worsening of renal function Details Spironolactone Amikacin Oral Inhalation Arikayce An increased risk of worsening of renal function Details Spironolactone Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Spironolactone Cisplatin Injection Platinol-AQ® An increased risk of worsening of renal function Details Spironolactone Gentamicin Injection Garamycin® I.V. An increased risk of worsening of renal function Details Spironolactone Gentamicin Ophthalmic Garamycin® Ophthalmic An increased risk of worsening of renal function Details Spironolactone Gentamicin Topical Garamycin® An increased risk of worsening of renal function Details Spironolactone Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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