Spironolactone

71 interactions 5 explained in plain English

Also sold as: Aldactone Carospir

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Colchicine Bromfenac Ophthalmic Perindopril Enoxaparin Injection Aspirin Arsenic Trioxide

1 Contraindicated 60 Major 9 Moderate 1 Minor

All (71) Contraindicated (1) Major (60) Moderate (9) Minor (1)

Major

Spironolactone Ibuprofen Addaprin Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Irbesartan Avapro An increased risk of hyperkalemia, an increased risk of hypotension and an increased risk of worsening of renal function Details Spironolactone Ketoprofen Actron® Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Ketorolac Acular Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Ketorolac Injection Acular Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Ketorolac Nasal Spray Sprix Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Ketorolac Ophthalmic Acular Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Lefamulin Xenleta Increased lefamulin exposure and an increased risk of lefamulin-related adverse reactions Details Spironolactone Lithium Carbonate Lithobid Increased lithium exposure and increased risk of lithium toxicity (weakness, tremor, excessive thirst, confusion) Details Spironolactone Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Spironolactone Losartan Arbli An increased risk of hyperkalemia, an increased risk of hypotension and an increased risk of worsening of renal function Details Spironolactone Meclofenamate Meclodium® Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Mefenamic Acid Ponstel® Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Meloxicam Alloxate Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Meloxicam Injection Alloxate Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Moexipril Univasc® Increased risk of hyperkalemia Details Spironolactone Morphine Injection Astramorph® PF Increased morphine exposure, an increased risk of morphine-related adverse effects (hypotension, respiratory depression, profound... Details Spironolactone Nabumetone Relafen Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Naproxen Aleve Reduced diuretic effectiveness, hyperkalemia, or possible nephrotoxicity Details Spironolactone Perindopril Aceon Increased risk of hyperkalemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.