St John's Wort

Contraindicated

St John's Wort Doravirine Pifeltro Reduced doravirine exposure, reduced efficacy of doravirine and an increased risk of doravirine resistance Details St John's Wort Fostemsavir Rukobia Reduced temsavir (the active moiety of fostemsavir) exposure and possible loss of virologic response Details St John's Wort Lenacapavir Injection Sunlenca Reduced lenacapavir exposure which may result in the loss of therapeutic effect and development of resistance to lenacapavir Details St John's Wort Lenacapavir Oral Sunlenca Reduced lenacapavir exposure which may result in the loss of therapeutic effect and development of resistance to lenacapavir Details St John's Wort Lurasidone Latuda Reduced lurasidone exposure Details St John's Wort Nifedipine Adalat® Reduced NIFEdipine exposure and reduced efficacy of NIFEdipine Details

Major

St John's Wort Acetaminophen And Codeine Capital® & Codeine Explained Reduced opioid efficacy, precipitation of opioid withdrawal, and an increased risk of serotonin syndrome Details St John's Wort Omeprazole Gastrobim Explained Reduced omeprazole exposure Details St John's Wort Sertraline Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details St John's Wort Buprenorphine Belbuca Explained Reduced buprenorphine exposure, reduced efficacy of buprenorphine and an increased risk of serotonin syndrome Details St John's Wort Relugolix Orgovyx Explained Altered relugolix exposure, an increased risk of relugolix-related adverse reactions and reduced efficacy of relugolix Details St John's Wort Abemaciclib Verzenio Explained Decreased abemaciclib plasma concentration Details St John's Wort Acalabrutinib Calquence Reduced acalabrutinib exposure Details St John's Wort Alpelisib Piqray Reduced alpelisib exposure and reduced efficacy of alpelisib Details St John's Wort Apixaban Eliquis Explained Reduced apixaban exposure, reduced efficacy of apixaban and an increased risk of stroke and other thromboembolic events Details St John's Wort Apremilast Otezla Reduced apremilast exposure and an reduced efficacy of apremilast Details St John's Wort Aripiprazole Injection Abilify Reduced ARIPiprazole exposure Details St John's Wort Asciminib Scemblix Reduced asciminib exposure and reduced efficacy of asciminib Details St John's Wort Atogepant Qulipta Reduced atogepant exposure Details St John's Wort Avapritinib Ayvakit Reduced avapritinib exposure and reduced efficacy of avapritinib Details St John's Wort Belumosudil Rezurock Explained Reduced belumosudil exposure and reduced efficacy of belumosudil Details St John's Wort Betrixaban Bevyxxa® Decreased betrixaban exposure Details St John's Wort Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details St John's Wort Abiraterone Abirtega Reduced abiraterone exposure and reduced efficacy of abiraterone Details St John's Wort Afatinib Gilotrif Decreased afatinib exposure Details St John's Wort Aficamten Reduced aficamten exposure and reduced efficacy of aficamten Details St John's Wort Amlodipine Amvaz® Reduced amLODIPine exposure Details St John's Wort Axitinib Inlyta Reduced axitinib exposure Details St John's Wort Bedaquiline Sirturo Reduced bedaquiline exposure and reduced efficacy of bedaquiline Details St John's Wort Bortezomib Boruzu Reduced bortezomib exposure Details St John's Wort Bosutinib Bosulif Reduced bosutinib exposure and reduced efficacy of bosutinib Details St John's Wort Brexpiprazole Rexulti Reduced brexpiprazole exposure Details St John's Wort Brigatinib Alunbrig Reduced brigatinib efficacy Details St John's Wort Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details St John's Wort Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details St John's Wort Cabozantinib Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details St John's Wort Cabozantinib (Thyroid Cancer) Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details St John's Wort Capmatinib Tabrecta Decreased capmatinib exposure and reduction of antitumor activity Details St John's Wort Chloroprocaine An increased risk of cardiovascular collapse and/or delayed emergence from anesthesia Details St John's Wort Cobimetinib Cotellic Decreased cobimetinib plasma concentrations Details