Sufentanil
56 interactions 5 explained in plain English
Also sold as:
Dsuvia
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
· Updated Jul 4, 2026
· Editorial policy
· Data sources
Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →
Most serious with:
Butorphanol Injection
Lenacapavir Injection
Sertraline
Cetirizine Ophthalmic
Palonosetron Injection
Diphenhydramine Topical
Major
Sufentanil Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Sufentanil Amitriptyline Elavil Explained Increased risk of serotonin syndrome and an increased risk of paralytic ileus Details Sufentanil Sertraline Explained Increased risk of serotonin syndrome Details Sufentanil Buprenorphine Belbuca Explained Reduced analgesic effect of SUFentanil and an increased risk of serotonin syndrome Details Sufentanil Trospium / Xanomeline Cobenfy Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Sufentanil Aripiprazole Injection Abilify Reduced pulmonary arterial pressure, increased risk for hypotension, profound sedation, respiratory depression, coma, and death Details Sufentanil Asenapine Transdermal Patch Secuado Reduced pulmonary arterial pressure, increased risk for hypotension, profound sedation, respiratory depression, coma, and death Details Sufentanil Aclidinium Oral Inhalation Tudorza Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Sufentanil Atropine Ophthalmic Atropine Care 1% Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Sufentanil Butorphanol Injection Butorphic Reduced analgesic effect of SUFentanil and an increased risk of serotonin syndrome Details Sufentanil Butorphanol Nasal Spray Stadol® NS Reduced analgesic effect of SUFentanil and an increased risk of serotonin syndrome Details Sufentanil Cetirizine Injection Aller-Tec Reduced pulmonary arterial pressure, increased risk for hypotension, profound sedation, respiratory depression, coma, and death Details Sufentanil Cetirizine Ophthalmic Zerviate Reduced pulmonary arterial pressure, increased risk for hypotension, profound sedation, respiratory depression, coma, and death Details Sufentanil Clopidogrel Plavix Reduced efficacy of clopidogrel Details Sufentanil Cyclopentolate Ophthalmic Akpentolate® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Sufentanil Cyclosporine Injection Atopica Increased SUFentanil exposure and an increased risk of respiratory depression Details Sufentanil Cyclosporine Ophthalmic Cequa Increased SUFentanil exposure and an increased risk of respiratory depression Details Sufentanil Dexamethasone Injection Decadron Reduced SUFentanil exposure Details Sufentanil Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Reduced SUFentanil exposure Details Sufentanil Diazepam Nasal Spray Valtoco Reduced pulmonary arterial pressure, increased risk for hypotension, profound sedation, respiratory depression, coma, and death Details Sufentanil Diazepam Rectal Diastat Reduced pulmonary arterial pressure, increased risk for hypotension, profound sedation, respiratory depression, coma, and death Details Sufentanil Diphenhydramine Injection Banophen Increased risk for hypotension, profound sedation, respiratory depression, coma, and death, increased risk of urinary retention an... Details Sufentanil Diphenhydramine Topical Afterbite with Antihistamine Increased risk for hypotension, profound sedation, respiratory depression, coma, and death, increased risk of urinary retention an... Details Sufentanil Dolasetron Anzemet Increased risk of serotonin syndrome Details Sufentanil Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Sufentanil Esketamine Nasal Spray Spravato Reduced pulmonary arterial pressure, increased risk for hypotension, profound sedation, respiratory depression, coma, and death Details Sufentanil Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Sufentanil Furosemide Injection Disal Reduced efficacy of diuretics Details Sufentanil Glycopyrronium Topical Cuvposa® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Sufentanil Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Sufentanil Granisetron Injection Granisol Increased risk of serotonin syndrome Details Sufentanil Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Sufentanil Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Sufentanil Hydroxychloroquine Plaquenil An increased risk of seizures Details Sufentanil Ipratropium Nasal Spray Atrovent Nasal Spray® Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Sufentanil Ipratropium Oral Inhalation Atrovent® HFA Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Sufentanil Ketoconazole Topical Extina® Foam Increased SUFentanil exposure and an increased risk of respiratory depression Details Sufentanil Lacosamide Injection Motpoly An increased risk of CNS depression Details Sufentanil Lenacapavir Injection Sunlenca Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-mediated adverse reactions Details Sufentanil Lenacapavir Oral Sunlenca Increased CYP3A substrate exposure and an increased risk of CYP3A substrate-mediated adverse reactions DetailsNo interactions on this page match that filter — try the next page or clear the filter.
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