Sulfacetamide

Name: Sulfacetamide Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

8 interactions

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Methotrexate Methotrexate Injection

2 Major 6 Moderate

All (8) Major (2) Moderate (6)

Major

Sulfacetamide Methotrexate Jylamvo Increased methotrexate exposure, decreased metabolite formation and increased risk of adverse events and decreased efficacy Details Sulfacetamide Methotrexate Injection Abitrexate® Increased methotrexate exposure, decreased metabolite formation and increased risk of adverse events and decreased efficacy Details

Moderate

Sulfacetamide Glimepiride Amaryl Increased risk of hypoglycemia Details Sulfacetamide Glipizide Glucotrol Increased risk of hypoglycemia Details Sulfacetamide Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Increased risk of hypoglycemia Details Sulfacetamide Insulin Detemir (Rdna Origin) Injection Levemir Increased risk of hypoglycemia Details Sulfacetamide Insulin Glulisine (Rdna Origin) Injection Apidra Increased risk of hypoglycemia Details Sulfacetamide Nateglinide Starlix® Increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.