Sulfadiazine

Name: Sulfadiazine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

13 interactions

Also sold as: Microsulfon®

About Sulfadiazine

Sulfadiazine, a sulfa drug, eliminates bacteria that cause infections, especially urinary tract infections. Antibiotics will not work for colds, flu, or other viral infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Read the full Sulfadiazine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Meloxicam Meloxicam Injection Methotrexate Methotrexate Injection

4 Major 9 Moderate

All (13) Major (4) Moderate (9)

Moderate

Sulfadiazine Chloroprocaine Antagonism of the sulfonamide's antibacterial effect Details Sulfadiazine Cyclosporine Injection Atopica Decreased cycloSPORINE effectiveness Details Sulfadiazine Cyclosporine Ophthalmic Cequa Decreased cycloSPORINE effectiveness Details Sulfadiazine Glimepiride Amaryl Increased risk of hypoglycemia Details Sulfadiazine Glipizide Glucotrol Increased risk of hypoglycemia Details Sulfadiazine Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Increased risk of hypoglycemia Details Sulfadiazine Insulin Detemir (Rdna Origin) Injection Levemir Increased risk of hypoglycemia Details Sulfadiazine Insulin Glulisine (Rdna Origin) Injection Apidra Increased risk of hypoglycemia Details Sulfadiazine Nateglinide Starlix® Increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.