Sulfasalazine

Name: Sulfasalazine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

47 interactions

Also sold as: Azulfidine Azulfidine® Azulfidine® EN-tabs®

About Sulfasalazine

Sulfasalazine is used to treat ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum) and also to maintain improvement of ulcerative colitis symptoms. Sulfasalazine delayed-release (Azulfidine EN-tabs) is also used to treat rheumatoid arthritis in adults… Read the full Sulfasalazine drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Injection Ketorolac Ophthalmic Ketorolac Nasal Spray Ketorolac Naproxen Bromfenac Ophthalmic

4 Contraindicated 34 Major 9 Moderate

All (47) Contraindicated (4) Major (34) Moderate (9)

Moderate

Sulfasalazine Cyclosporine Ophthalmic Cequa Loss of cycloSPORINE efficacy Details Sulfasalazine Encorafenib Braftovi Increased BCRP substrate exposure and an increased risk of BCRP substrate-related toxicities Details Sulfasalazine Folic Acid Folacin Reduced folic acid exposure and reduced efficacy of folic acid Details Sulfasalazine Furosemide Injection Disal An increased risk of salicylate toxicity Details Sulfasalazine Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Increased risk of hypoglycemia Details Sulfasalazine Insulin Detemir (Rdna Origin) Injection Levemir Increased risk of hypoglycemia Details Sulfasalazine Insulin Glulisine (Rdna Origin) Injection Apidra Increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.