Sulfasalazine

47 interactions
Also sold as: Azulfidine Azulfidine® Azulfidine® EN-tabs®
About Sulfasalazine

Sulfasalazine is used to treat ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum) and also to maintain improvement of ulcerative colitis symptoms. Sulfasalazine delayed-release (Azulfidine EN-tabs) is also used to treat rheumatoid arthritis in adults… Read the full Sulfasalazine drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Injection Ketorolac Ophthalmic Ketorolac Nasal Spray Ketorolac Naproxen Bromfenac Ophthalmic
4 Contraindicated 34 Major 9 Moderate
All (47) Contraindicated (4) Major (34) Moderate (9)

Contraindicated

Sulfasalazine Ketorolac Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Sulfasalazine Ketorolac Injection Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Sulfasalazine Ketorolac Nasal Spray Sprix Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details Sulfasalazine Ketorolac Ophthalmic Acular Enhanced gastrointestinal adverse effects (peptic ulcers, gastrointestinal bleeding and/or perforation) Details

Major

Sulfasalazine Amoxicillin Amoxi Drop An increased risk of drug reaction with eosinophilia and systemic symptoms Details Sulfasalazine Asciminib Scemblix Increased BCRP substrate exposure and an increased risk of BCRP substrate-related adverse effects Details Sulfasalazine Azathioprine Azasan An increased risk of myelosuppression and an increased risk of bone marrow suppression Details Sulfasalazine Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Sulfasalazine Capmatinib Tabrecta Increased BCRP substrate exposure and an increased risk of adverse reactions Details Sulfasalazine Darolutamide Nubeqa Increased plasma concentrations of BCRP substrates Details Sulfasalazine Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Sulfasalazine Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Sulfasalazine Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Sulfasalazine Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Sulfasalazine Digoxin Cardoxin® Reduced digoxin exposure Details Sulfasalazine Enasidenib Idhifa Increased exposure of BCRP substrate Details Sulfasalazine Etodolac Lodine Increased risk of bleeding Details Sulfasalazine Fenoprofen Fenopron Increased risk of bleeding Details Sulfasalazine Flurbiprofen Ansaid Increased risk of bleeding Details Sulfasalazine Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Sulfasalazine Hydrocortisone Ala-Cort An increased risk of gastrointestinal adverse reactions, reduced salicylate exposure and an increased risk of salicylate toxicity... Details Sulfasalazine Hydrocortisone Injection A-Hydrocort® An increased risk of gastrointestinal adverse reactions, reduced salicylate exposure and an increased risk of salicylate toxicity... Details Sulfasalazine Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Sulfasalazine Ketoprofen Actron® Increased risk of bleeding Details Sulfasalazine Leflunomide Arava Increased exposure of BCRP substrate Details Sulfasalazine Leniolisib Joenja Increased BCRP substrate exposure Details Sulfasalazine Meclofenamate Meclodium® Increased risk of bleeding Details Sulfasalazine Mefenamic Acid Ponstel® Increased risk of bleeding Details Sulfasalazine Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Sulfasalazine Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Sulfasalazine Mercaptopurine Purinethol® An increased risk of myelosuppression and an increased risk of bone marrow suppression Details Sulfasalazine Mesalamine Apriso Increased risk of bleeding Details Sulfasalazine Mesalamine Rectal Canasa Increased risk of bleeding Details Sulfasalazine Methotrexate Jylamvo An increased risk of hepatotoxicity, increased methotrexate exposure, an increased risk of methotrexate-related severe adverse rea... Details Sulfasalazine Methotrexate Injection Abitrexate® An increased risk of hepatotoxicity, increased methotrexate exposure, an increased risk of methotrexate-related severe adverse rea... Details Sulfasalazine Midostaurin Rydapt Increased BCRP substrate exposure Details Sulfasalazine Nabumetone Relafen Increased risk of bleeding Details Sulfasalazine Naproxen Aleve Increased risk of bleeding Details

Moderate

Sulfasalazine Chloroprocaine Antagonism of the sulfonamide's antibacterial effect Details Sulfasalazine Cyclosporine Injection Atopica Loss of cycloSPORINE efficacy Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.