Sunvozertinib

16 interactions 1 explained in plain English
Also sold as: Zegfrovy
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Medroxyprogesterone Ketoconazole Topical Levonorgestrel Levonorgestrel Intrauterine System Mitapivat Nafcillin Injection
16 Major
All (16) Major (16)

Major

Sunvozertinib Colchicine Colcrys Explained Increased P-gp substrates with NTI exposure and increased risk of P-gp substrates with NTI-related adverse effects Details Sunvozertinib Cyclosporine Injection Atopica Increased P-gp substrates with NTI exposure and increased risk of P-gp substrates with NTI-related adverse effects Details Sunvozertinib Cyclosporine Ophthalmic Cequa Increased P-gp substrates with NTI exposure and increased risk of P-gp substrates with NTI-related adverse effects Details Sunvozertinib Digoxin Cardoxin® Increased P-gp substrates with NTI exposure and increased risk of P-gp substrates with NTI-related adverse effects Details Sunvozertinib Encorafenib Braftovi Reduced sunvozertinib exposure and reduced efficacy of sunvozertinib Details Sunvozertinib Estradiol Delestrogen Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Sunvozertinib Estradiol Topical Divigel Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Sunvozertinib Estradiol Transdermal Patch Alora® Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Sunvozertinib Everolimus Afinitor Increased P-gp substrates with NTI exposure and increased risk of P-gp substrates with NTI-related adverse effects Details Sunvozertinib Ketoconazole Topical Extina® Foam Increased sunvozertinib exposure and an increased risk sunvozertinib-related adverse reactions Details Sunvozertinib Levonorgestrel After banger Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Sunvozertinib Levonorgestrel Intrauterine System Kyleena Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Sunvozertinib Medroxyprogesterone Amen® Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Sunvozertinib Medroxyprogesterone Injection Depo-Provera Reduced hormonal contraceptives exposure and reduced efficacy of hormonal contraceptives Details Sunvozertinib Mitapivat Aqvesme Reduced sunvozertinib exposure and reduced efficacy of sunvozertinib Details Sunvozertinib Nafcillin Injection Unipen® Injection Reduced sunvozertinib exposure and reduced efficacy of sunvozertinib Details

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