Taletrectinib

80 interactions 6 explained in plain English

Also sold as: Ibtrozi

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Acebutolol Esmolol Oxaliplatin Injection Dasatinib Ofloxacin

1 Contraindicated 78 Major 1 Moderate

All (80) Contraindicated (1) Major (78) Moderate (1)

Major

Taletrectinib Gatifloxacin Ophthalmic Zymar® Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Gemifloxacin Factive Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Glasdegib Daurismo Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Goserelin Implant Zoladex Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Granisetron Transdermal Patch Sancuso Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Granisetron Injection Granisol Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Histrelin Implant Supprelin Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Ivabradine Corlanor Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Lansoprazole Prevacid Reduced taletrectinib exposure and reduced efficacy of taletrectinib Details Taletrectinib Lefamulin Xenleta Increased taletrectinib exposure, an increased risk of taletrectinib-related adverse reactions, increased risk of QT interval prol... Details Taletrectinib Lenacapavir Injection Sunlenca Increased taletrectinib exposure and an increased risk of taletrectinib-related adverse reactions Details Taletrectinib Lenacapavir Oral Sunlenca Increased taletrectinib exposure and an increased risk of taletrectinib-related adverse reactions Details Taletrectinib Lenvatinib Lenvima Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Letermovir Injection Prevymis Increased taletrectinib exposure and an increased risk of taletrectinib-related adverse reactions Details Taletrectinib Levofloxacin Levaquin Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Levofloxacin Injection Levaquin Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Taletrectinib Mefloquine Lariam® Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Metronidazole Flagyl Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Metronidazole Injection Flagyl Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Metronidazole Topical MetroCream® Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Metronidazole Vaginal MetroGel® Vaginal Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Mexiletine Mexitil® Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Mitapivat Aqvesme Reduced taletrectinib exposure and reduced efficacy of taletrectinib Details Taletrectinib Moxifloxacin Avelox Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Moxifloxacin Injection Avelox Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Nafarelin Nasal Spray Synarel Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Nafcillin Injection Unipen® Injection Reduced taletrectinib exposure and reduced efficacy of taletrectinib Details Taletrectinib Nizatidine Axid® Reduced taletrectinib exposure and reduced efficacy of taletrectinib Details Taletrectinib Octreotide Bynfezia Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Octreotide Injection Bynfezia Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Ofloxacin Floxin® Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Ofloxacin Ophthalmic Ocuflox Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Ofloxacin Otic Floxin® Otic Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Taletrectinib Oxaliplatin Injection Eloxatin® Increased risk of QT interval prolongation and torsade de pointes Details

Moderate

Taletrectinib Levothyroxine Ermeza Increased risk of hypothyroidism Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.