Taletrectinib

80 interactions 6 explained in plain English

Also sold as: Ibtrozi

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Acebutolol Esmolol Oxaliplatin Injection Dasatinib Ofloxacin

1 Contraindicated 78 Major 1 Moderate

All (80) Contraindicated (1) Major (78) Moderate (1)

Contraindicated

Taletrectinib Ketoconazole Topical Extina® Foam Increased CYP3A4 substrate exposure and an increased risk of QT interval prolongation Details

Major

Taletrectinib Omeprazole Gastrobim Explained Reduced taletrectinib exposure and reduced efficacy of taletrectinib Details Taletrectinib Amitriptyline Elavil Explained Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Sertraline Explained Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Buprenorphine Belbuca Explained Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Taletrectinib Amisulpride Injection Barhemsys Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Arsenic Trioxide Trisenox Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Aripiprazole Injection Abilify Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Arsenic Trioxide Injection Trisenox Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Atenolol Tenormin Explained Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Azithromycin AzaSite Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Acebutolol Sectral® Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Alfuzosin UroXatral Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Anagrelide Agrylin Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Atropine Ophthalmic Atropine Care 1% Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Bedaquiline Sirturo Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Chloroquine Aralen® Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Dasatinib Phyrago Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Degarelix Injection Firmagon Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Deutetrabenazine Austedo Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Dexlansoprazole Dexilant Reduced taletrectinib exposure and reduced efficacy of taletrectinib Details Taletrectinib Digoxin Cardoxin® Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Disopyramide Norpace Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Dofetilide Tikosyn Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Dolasetron Anzemet Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Dolasetron Injection Anzemet Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Encorafenib Braftovi Reduced taletrectinib exposure, reduced efficacy of taletrectinib, increased risk of QT interval prolongation, and torsade de poin... Details Taletrectinib Entrectinib Rozlytrek Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Eribulin Injection Halaven Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Esmolol Brevibloc Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Esomeprazole Nexium Reduced taletrectinib exposure and reduced efficacy of taletrectinib Details Taletrectinib Esomeprazole Injection Nexium Reduced taletrectinib exposure and reduced efficacy of taletrectinib Details Taletrectinib Famotidine Calmicid Reduced taletrectinib exposure, reduced efficacy of taletrectinib, increased risk of QT interval prolongation and torsade de point... Details Taletrectinib Famotidine Injection Calmicid Reduced taletrectinib exposure, reduced efficacy of taletrectinib, increased risk of QT interval prolongation and torsade de point... Details Taletrectinib Felbamate Felbatol Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Flecainide Tambocor® Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Foscarnet Injection Foscavir Increased risk of QT interval prolongation and torsade de pointes Details Taletrectinib Galantamine Razadyne Increased risk of QT interval prolongation and torsade de pointes Details

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