Tegafur

47 interactions 1 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Fluorouracil Fluorouracil Topical Flucytosine Capecitabine Fluorouracil Injection Leucovorin Injection
5 Contraindicated 40 Major 2 Minor
All (47) Contraindicated (5) Major (40) Minor (2)

Contraindicated

Tegafur Capecitabine Xeloda Increased antineoplastic toxicity Details Tegafur Flucytosine Increased antineoplastic toxicity Details Tegafur Fluorouracil Adrucil Increased antineoplastic toxicity Details Tegafur Fluorouracil Injection Adrucil Increased antineoplastic toxicity Details Tegafur Fluorouracil Topical Carac Increased antineoplastic toxicity Details

Major

Tegafur Abrocitinib Cibinqo Explained Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Allopurinol Aloprim Reduced capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure and... Details Tegafur Allopurinol Injection Aloprim Reduced capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure and... Details Tegafur Avatrombopag Doptelet Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Benznidazole Increased exposure of 5-fluorouracil Details Tegafur Aficamten Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Amlodipine Amvaz® Decreased exposure of 5-fluorouracil Details Tegafur Deuruxolitinib Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Diclofenac Ophthalmic Voltaren® Eye Drops Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Diclofenac Topical (Actinic Keratosis) Pennsaid Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Diclofenac Topical (Arthritis Pain) Pennsaid® Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Diclofenac Transdermal Patch Flector Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Dronabinol Marinol Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Erdafitinib Balversa Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Flurbiprofen Ansaid Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Flurbiprofen Ophthalmic Ocufen Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Fluvastatin Lescol Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Folic Acid Folacin Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Tegafur Glimepiride Amaryl Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Glipizide Glucotrol Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Ibuprofen Addaprin Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Irbesartan Avapro Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Letrozole Femara Decreased exposure of 5-fluorouracil Details Tegafur Leucovorin Vykoura Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Tegafur Leucovorin Injection Vykoura Increased capecitabine or doxifluridine or fluorouracil (prodrugs of capecitabine) or tegafur (prodrug of fluorouracil) exposure a... Details Tegafur Losartan Arbli Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Macitentan Opsumit Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Meloxicam Alloxate Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Meloxicam Injection Alloxate Increased exposure of CYP2C9 substrates and an increased risk of CYP2C9 substrates-related adverse effects Details Tegafur Methimazole Felanorm Decreased exposure of 5-fluorouracil Details Tegafur Methotrexate Jylamvo Increased 5-fluorouracil toxicity Details Tegafur Methotrexate Injection Abitrexate® Increased 5-fluorouracil toxicity Details Tegafur Metronidazole Flagyl Increased exposure of 5-fluorouracil Details Tegafur Metronidazole Injection Flagyl Increased exposure of 5-fluorouracil Details Tegafur Metronidazole Topical MetroCream® Increased exposure of 5-fluorouracil Details

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