Telotristat Ethyl

31 interactions 3 explained in plain English
Also sold as: Xermelo
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Telotristat Ethyl Acetaminophen And Codeine Capital® & Codeine Explained Reduced codeine and morphine exposure, reduced opioid efficacy and precipitation of opioid withdrawal Details Telotristat Ethyl Buprenorphine Belbuca Explained Reduced buprenorphine exposure and reduced efficacy of buprenorphine Details Telotristat Ethyl Atogepant Qulipta Reduced atogepant exposure Details Telotristat Ethyl Avapritinib Ayvakit Reduced avapritinib exposure and reduced efficacy of avapritinib Details Telotristat Ethyl Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Telotristat Ethyl Aficamten Reduced aficamten exposure and reduced efficacy of aficamten Details Telotristat Ethyl Amlodipine Amvaz® Reduced amLODIPine exposure Details Telotristat Ethyl Bedaquiline Sirturo Reduced bedaquiline exposure and reduced efficacy of bedaquiline Details Telotristat Ethyl Cabozantinib Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Telotristat Ethyl Cabozantinib (Thyroid Cancer) Cabometyx Reduced cabozantinib exposure and reduced efficacy of cabozantinib Details Telotristat Ethyl Cyclosporine Injection Atopica Reduced cycloSPORINE exposure Details Telotristat Ethyl Cyclosporine Ophthalmic Cequa Reduced cycloSPORINE exposure Details Telotristat Ethyl Doravirine Pifeltro Reduced doravirine exposure and reduced efficacy of doravirine Details Telotristat Ethyl Entrectinib Rozlytrek Reduced entrectinib exposure and reduced efficacy of entrectinib Details Telotristat Ethyl Erdafitinib Balversa Reduced erdafitinib exposure Details Telotristat Ethyl Fentanyl Transdermal Patch Duragesic® Reduced exposure of fentaNYL, reduced efficacy of fentaNYL and/or onset of opioid withdrawal symptoms Details Telotristat Ethyl Finerenone Kerendia Reduced finerenone exposure and reduced efficacy of finerenone Details Telotristat Ethyl Lefamulin Xenleta Reduced lefamulin exposure and reduced efficacy of lefamulin Details Telotristat Ethyl Lenacapavir Injection Sunlenca Reduced lenacapavir exposure which may result in the loss of therapeutic effect and development of resistance to lenacapavir Details Telotristat Ethyl Lenacapavir Oral Sunlenca Reduced lenacapavir exposure which may result in the loss of therapeutic effect and development of resistance to lenacapavir Details Telotristat Ethyl Leniolisib Joenja Reduced leniolisib exposure and reduced efficacy of leniolisib Details Telotristat Ethyl Levonorgestrel After banger Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Telotristat Ethyl Levonorgestrel Intrauterine System Kyleena Reduced levonorgestrel exposure and increased risk of breakthrough bleeding and/or contraceptive failure Details Telotristat Ethyl Lumateperone Caplyta Reduced lumateperone exposure Details Telotristat Ethyl Lurasidone Latuda Reduced lurasidone exposure Details Telotristat Ethyl Mitapivat Aqvesme Reduced mitapivat exposure and reduced efficacy of mitapivat Details Telotristat Ethyl Nifedipine Adalat® Reduced NIFEdipine exposure Details

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