Tenofovir Disoproxil Fumarate

31 interactions
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Aspirin Etodolac Bromfenac Ophthalmic Diclofenac Ophthalmic Mefenamic Acid Ibuprofen
25 Major 6 Moderate
All (31) Major (25) Moderate (6)

Major

Tenofovir Disoproxil Fumarate Aspirin Acuprin® Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Aspirin Rectal Aspirin Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Bromfenac Ophthalmic Bromday® Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Diclofenac Transdermal Patch Flector Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Didanosine Videx® Increased didanosine plasma concentrations and risk of didanosine toxicity (neuropathy, diarrhea, pancreatitis, severe lactic acid... Details Tenofovir Disoproxil Fumarate Etodolac Lodine Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Fenoprofen Fenopron Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Flurbiprofen Ansaid Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Flurbiprofen Ophthalmic Ocufen Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Ibuprofen Addaprin Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Ketoprofen Actron® Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Ketorolac Acular Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Ketorolac Injection Acular Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Ketorolac Nasal Spray Sprix Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Ketorolac Ophthalmic Acular Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Meclofenamate Meclodium® Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Mefenamic Acid Ponstel® Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Meloxicam Alloxate Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Meloxicam Injection Alloxate Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Nabumetone Relafen Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Naproxen Aleve Increased risk of acute renal failure Details Tenofovir Disoproxil Fumarate Orlistat Alli Reduced efficacy of antiretrovirals, loss of virological control Details

Moderate

Tenofovir Disoproxil Fumarate Cyclosporine Injection Atopica Increased tenofovir alafenamide or tenofovir disoproxil fumarate exposure Details Tenofovir Disoproxil Fumarate Cyclosporine Ophthalmic Cequa Increased tenofovir alafenamide or tenofovir disoproxil fumarate exposure Details Tenofovir Disoproxil Fumarate Elacestrant Orserdu Increased tenofovir alafenamide or tenofovir disoproxil fumarate exposure Details Tenofovir Disoproxil Fumarate Fostamatinib Tavalisse Increased tenofovir alafenamide or tenofovir disoproxil fumarate exposure Details Tenofovir Disoproxil Fumarate Lenacapavir Injection Sunlenca Increased tenofovir alafenamide or tenofovir disoproxil fumarate exposure Details Tenofovir Disoproxil Fumarate Lenacapavir Oral Sunlenca Increased tenofovir alafenamide or tenofovir disoproxil fumarate exposure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.