Tetracycline

27 interactions 1 explained in plain English
Also sold as: Achromycin V® Sumycin® Viabecline Vitastem
About Tetracycline

Tetracycline is an antibiotic used to treat bacterial infections including respiratory, skin, urinary, and tick-borne infections, plus acne. Read the full Tetracycline drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acitretin Isotretinoin Penicillin G Benzathine Injection Penicillin G Procaine Injection Penicillin V Potassium Estradiol Transdermal Patch
1 Contraindicated 19 Major 7 Moderate
All (27) Contraindicated (1) Major (19) Moderate (7)

Major

Tetracycline Isotretinoin Absorica Explained An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Tetracycline Amoxicillin Amoxi Drop Decreased antibacterial effectiveness Details Tetracycline Ampicillin Amcill® Decreased antibacterial effectiveness Details Tetracycline Ampicillin Injection Omnipen-N® Decreased antibacterial effectiveness Details Tetracycline Bexarotene Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Tetracycline Bexarotene Topical Targretin An increased risk of pseudotumor cerebri (benign intracranial hypertension) Details Tetracycline Digoxin Cardoxin® Increased digoxin exposure Details Tetracycline Estradiol Delestrogen Decreased contraceptive effectiveness Details Tetracycline Estradiol Topical Divigel Decreased contraceptive effectiveness Details Tetracycline Estradiol Transdermal Patch Alora® Decreased contraceptive effectiveness Details Tetracycline Exenatide Injection Bydureon Reduced oral antibiotics absorption and reduced efficacy of oral antibiotics Details Tetracycline Levonorgestrel After banger Decreased contraceptive effectiveness Details Tetracycline Levonorgestrel Intrauterine System Kyleena Decreased contraceptive effectiveness Details Tetracycline Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Tetracycline Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Tetracycline Nafcillin Injection Unipen® Injection Decreased antibacterial effectiveness Details Tetracycline Penicillin G Benzathine Injection Bicillin Decreased antibacterial effectiveness Details Tetracycline Penicillin G Procaine Injection Bactracillin G Decreased antibacterial effectiveness Details Tetracycline Penicillin V Potassium Beepen-VK® Decreased antibacterial effectiveness Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.