Tetracycline

Name: Tetracycline Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

27 interactions 1 explained in plain English

Also sold as: Achromycin V® Sumycin® Viabecline Vitastem

About Tetracycline

Tetracycline is an antibiotic used to treat bacterial infections including respiratory, skin, urinary, and tick-borne infections, plus acne. Read the full Tetracycline drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Acitretin Isotretinoin Penicillin G Benzathine Injection Penicillin G Procaine Injection Penicillin V Potassium Estradiol Transdermal Patch

1 Contraindicated 19 Major 7 Moderate

All (27) Contraindicated (1) Major (19) Moderate (7)

Moderate

Tetracycline Atovaquone Mepron Reduction of atovaquone plasma concentrations Details Tetracycline Cholestyramine Resin Locholest® Decreased tetracycline absorption Details Tetracycline Colestipol Colestid Decreased tetracycline effectiveness Details Tetracycline Folic Acid Folacin Reduced tetracycline exposure and reduced efficacy of tetracycline Details Tetracycline Glimepiride Amaryl Increased blood glucose lowering effect and increased risk of hypoglycemia Details Tetracycline Lanthanum Fosrenol® Reduced bioavailability of tetracyclines Details Tetracycline Lixisenatide Injection Adlyxin® Delayed therapeutic effect Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.