Tezacaftor

15 interactions 3 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Letermovir Injection Lefamulin Lenacapavir Injection Lenacapavir Oral Mitapivat Nafcillin Injection
15 Major
All (15) Major (15)

Major

Tezacaftor Abametapir Explained Increased exposure of CYP3A4 substrate Details Tezacaftor Relugolix Orgovyx Explained Increased relugolix exposure Details Tezacaftor Colchicine Colcrys Explained Increased exposure to P-gp substrates and increased risk of P-gp substrates-related adverse effects Details Tezacaftor Cyclosporine Injection Atopica Increased exposure to P-gp substrates and increased risk of P-gp substrates-related adverse effects Details Tezacaftor Cyclosporine Ophthalmic Cequa Increased exposure to P-gp substrates and increased risk of P-gp substrates-related adverse effects Details Tezacaftor Digoxin Cardoxin® Increased exposure to P-gp substrates and increased risk of P-gp substrates-related adverse effects Details Tezacaftor Everolimus Afinitor Increased exposure to P-gp substrates and increased risk of P-gp substrates-related adverse effects Details Tezacaftor Ketoconazole Topical Extina® Foam Increased tezacaftor exposure and an increased risk of tezacaftor-related adverse reactions Details Tezacaftor Lefamulin Xenleta Increased tezacaftor exposure and an increased risk tezacaftor-related adverse reaction Details Tezacaftor Lenacapavir Injection Sunlenca Increased tezacaftor exposure and an increased risk tezacaftor-related adverse reaction Details Tezacaftor Lenacapavir Oral Sunlenca Increased tezacaftor exposure and an increased risk tezacaftor-related adverse reaction Details Tezacaftor Letermovir Injection Prevymis Increased tezacaftor exposure and an increased risk tezacaftor-related adverse reaction Details Tezacaftor Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Tezacaftor Mitapivat Aqvesme Reduced tezacaftor exposure and reduced efficacy of tezacaftor Details Tezacaftor Nafcillin Injection Unipen® Injection Reduced tezacaftor exposure and reduced efficacy of tezacaftor Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.