Thiethylperazine

26 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Thiethylperazine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Thiethylperazine Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Thiethylperazine Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Thiethylperazine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Thiethylperazine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Thiethylperazine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Thiethylperazine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Thiethylperazine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Thiethylperazine Diazepam Rectal Diastat Increased risk of CNS depression Details Thiethylperazine Esketamine Nasal Spray Spravato Increased risk of sedation Details Thiethylperazine Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Thiethylperazine Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Thiethylperazine Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Thiethylperazine Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Thiethylperazine Hydroxychloroquine Plaquenil An increased risk of seizures Details Thiethylperazine Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Thiethylperazine Lacosamide Injection Motpoly An increased risk of CNS depression Details Thiethylperazine Levodopa Oral Inhalation Inbrija Reduce efficacy of levodopa (foslevodopa), an increased risk of exacerbating psychosis [or symptoms of Parkinson's disease: delusi... Details Thiethylperazine Metoclopramide Injection Gimoti Increased risk of CNS depression Details Thiethylperazine Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Thiethylperazine Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Thiethylperazine Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Thiethylperazine Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Thiethylperazine Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.