Thioproperazine

Name: Thioproperazine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

5 interactions

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 11, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Cabergoline Hydroxychloroquine Levodopa Oral Inhalation Lithium Carbonate

4 Major 1 Moderate

All (5) Major (4) Moderate (1)

Major

Thioproperazine Cabergoline Dostinex® Reduced efficacy of cabergoline and reduced efficacy of dopamine-2 receptors Details Thioproperazine Hydroxychloroquine Plaquenil An increased risk of seizures Details Thioproperazine Levodopa Oral Inhalation Inbrija Reduced efficacy of levodopa and an increased risk of exacerbating psychosis (or symptoms of Parkinson's disease: delusion, confus... Details Thioproperazine Lithium Carbonate Lithobid Weakness, dyskinesias, increased extrapyramidal symptoms, encephalopathy, and brain damage Details

Moderate

Thioproperazine Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.