Thioridazine and Leniolisib: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Thioridazine
No brand names on recordLeniolisib
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Reduced leniolisib exposure and reduced efficacy of leniolisib
Interaction Deep Dive
Avoid concomitant use of leniolisib with moderate CYP3A4 inducers. Concomitant use of leniolisib with moderate CYP3A4 inducers may result in reduced leniolisib exposure and thus reduced leniolisib efficacy. PBPK model-based simulations predicted a maximum decrease of 58% in leniolisib AUC(0-12) with efavirenz (a moderate CYP3A4 inducer)1.
Why it happens (mechanism)
Induction of CYP3A4-mediated metabolism of leniolisib
Literature reports
1 report — tap to read
a) Physiologically-based pharmacokinetic (PBPK) model-based simulations predicted a maximum decrease of 58% in leniolisib AUC(0-12) with efavirenz (a moderate CYP3A4 inducer) 1.
Common questions
Can I take Thioridazine and Leniolisib together?
Reduced leniolisib exposure and reduced efficacy of leniolisib Always confirm with your pharmacist or prescriber before making any change.
How serious is the Thioridazine and Leniolisib interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Thioridazine or Leniolisib need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: JOENJA(R) oral tablets, leniolisib oral tablets. Pharming Healthcare, Inc (per FDA), Warren, NJ, 2025. DailyMed
Keep reading about Thioridazine
Keep reading about Leniolisib
These medications also interact with supplements
Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:
major · moderate · minor — check everything you take with our drug–supplement interaction checker.
Check another combination
Our instant two-drug interaction checker is almost here.
Still have questions about this combination?
Every question gets a real answer from a licensed pharmacist — free, and usually within a day.
Ask the pharmacist