Leniolisib

133 interactions 225 cited references

Also sold as: Joenja Joenja®

About Leniolisib

Leniolisib is used to treat adults and children 12 years of age and older who have activated phosphoinositide 3-kinase delta syndrome (APDS; an genetic condition that decreases the activity of the immune system and can result in recurrent infections, swollen lymph nodes and spleen, and a certain type of lymphoma [a typ… Read the full Leniolisib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 10, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ensitrelvir Adagrasib Adenovirus Vaccine Type 7, Live Atorvastatin Fluvastatin Adenovirus Vaccine Type 4, Live

1 Contraindicated 128 Major 4 Moderate

All (133) Contraindicated (1) Major (128) Moderate (4)

Contraindicated

Leniolisib Ensitrelvir Increased CYP3A substrates exposure and an increased risk of CYP3A substrates-related adverse effects Details

Major

Leniolisib Simvastatin Flolipid Increased BCRP/OATP1B1/OATP1B3 substrate exposure Details Leniolisib Alpelisib Piqray Increased BCRP substrate exposure Details Leniolisib Atogepant Qulipta Increased OATP1B1/OATP1B3 substrate exposure Details Leniolisib Atorvastatin Atorvaliq Increased OATP1B1/OATP1B3 substrate exposure Details Leniolisib Axitinib Inlyta Increased OATP1B1 substrate exposure Details Leniolisib Daprodustat Jesduvroq Increased OATP1B1/OATP1B3 substrate exposure Details Leniolisib Docetaxel Beizray Increased OATP1B1/OATP1B3 substrate exposure Details Leniolisib Docetaxel Injection Beizray Increased OATP1B1/OATP1B3 substrate exposure Details Leniolisib Eluxadoline Viberzi Increased OATP1B1 substrate exposure Details Leniolisib Encorafenib Braftovi Reduced leniolisib exposure and reduced efficacy of leniolisib Details Leniolisib Exemestane Aromasin Increased OATP1B1 substrate exposure Details Leniolisib Fexofenadine Allegra Increased OATP1B1/OATP1B3 substrate exposure Details Leniolisib Fluvastatin Lescol Increased OATP1B1/OATP1B3 substrate exposure Details Leniolisib Irinotecan Camptosar Increased BCRP substrate exposure Details Leniolisib Irinotecan Injection Camptosar Increased BCRP substrate exposure Details Leniolisib Ketoconazole Topical Extina® Foam Increased leniolisib exposure Details Leniolisib Adagrasib Krazati Increased leniolisib exposure Details Leniolisib Adenovirus Vaccine Type 4, Live Reduced efficacy of live attenuated vaccine Details Leniolisib Adenovirus Vaccine Type 7, Live Reduced efficacy of live attenuated vaccine Details Leniolisib Apalutamide Erleada Reduced leniolisib exposure and reduced efficacy of leniolisib Details Leniolisib Atrasentan Increased OATP1B1/OATP1B3 substrate exposure Details Leniolisib Avacopan Tavneos Increased CYP3A4 substrate exposure Details Leniolisib Bacillus Of Calmette And Guerin Vaccine, Live Reduced efficacy of live attenuated vaccine Details Leniolisib Boceprevir Increased leniolisib exposure Details Leniolisib Bosentan Increased bosentan exposure, reduced leniolisib exposure and reduced efficacy of leniolisib Details Leniolisib Carbamazepine Carbatrol Reduced leniolisib exposure and reduced efficacy of leniolisib Details Leniolisib Cenobamate Xcopri Reduced leniolisib exposure and reduced efficacy of leniolisib Details Leniolisib Ceritinib Zykadia Increased leniolisib exposure Details Leniolisib Cerivastatin Increased OATP1B1/OATP1B3 substrate exposure Details Leniolisib Cholera Vaccine, Live Reduced efficacy of live attenuated vaccine Details Leniolisib Clarithromycin Biaxin Increased leniolisib exposure Details Leniolisib Cobicistat Tybost Increased leniolisib exposure Details Leniolisib Conivaptan Vaprisol Increased CYP3A substrate exposure Details Leniolisib Dabrafenib Tafinlar Reduced leniolisib exposure and reduced efficacy of leniolisib Details Leniolisib Dengue Tetravalent Vaccine, Live Reduced efficacy of live attenuated vaccine Details Leniolisib Dipyrone Reduced leniolisib exposure and reduced efficacy of leniolisib Details Leniolisib Ebola Zaire Vaccine, Live Reduced efficacy of live attenuated vaccine Details Leniolisib Efavirenz Reduced leniolisib exposure and reduced efficacy of leniolisib Details Leniolisib Elagolix Orilissa Increased elagolix exposure, reduced leniolisib exposure and reduced efficacy of leniolisib Details

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