Ribociclib and Leniolisib: Interaction Details
AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature
Ribociclib
Leniolisib
How we grade severity & evidence
Severity levels
- Contraindicated: These should generally not be used together.
- Major: Potentially serious — often needs a change or close monitoring.
- Moderate: Can be significant — usually manageable with monitoring.
- Minor: Usually limited clinical impact.
Evidence grades
- Established: Well documented — supported by controlled studies or strong clinical data.
- Probable: Good supporting evidence, though not definitively proven.
- Suspected: Some evidence suggests this interaction, but it is not well established.
- Possible: Limited or conflicting evidence; the interaction may occur.
- Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.
Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.
What happens
Increased leniolisib exposure
Interaction Deep Dive
Avoid concomitant use of leniolisib with strong CYP3A4 inhibitors. Leniolisib is a substrate of CYP3A4. Concomitant use of leniolisib with strong CYP3A4 inhibitors may increase the exposure of leniolisib. In a drug interaction study, leniolisib exposure was increased approximately 2-fold when coadministered with itraconazole, a strong CYP3A4 inhibitor1.
Why it happens (mechanism)
Inhibition of CYP3A4-mediated metabolism of leniolisib
Literature reports
1 report — tap to read
a) Leniolisib is a substrate of CYP3A4. In a drug interaction study, leniolisib exposure was increased approximately 2-fold when coadministered with itraconazole, a strong CYP3A4 inhibitor 1.
Common questions
Can I take Ribociclib and Leniolisib together?
Increased leniolisib exposure Always confirm with your pharmacist or prescriber before making any change.
How serious is the Ribociclib and Leniolisib interaction?
It is rated major. Potentially serious — often needs a change or close monitoring.
How quickly could this interaction happen?
The documented onset is "unspecified". The timing of this interaction is not well characterized.
How strong is the evidence for this interaction?
The evidence is graded "probable". Good supporting evidence, though not definitively proven.
Questions for your pharmacist
- Does my dose of Ribociclib or Leniolisib need adjusting while I take them together?
- What symptoms should prompt me to call you or my prescriber right away?
- Does the timing of my doses matter for this combination?
- Is there a safer alternative to one of these medications for me?
References (1)
- Product Information: JOENJA(R) oral tablets, leniolisib oral tablets. Pharming Healthcare, Inc (per FDA), Warren, NJ, 2025. DailyMed
Keep reading about Ribociclib
Keep reading about Leniolisib
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