Tianeptine

47 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Tianeptine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Tianeptine Sertraline Explained An increased risk of serotonin syndrome Details Tianeptine Albuterol Oral Inhalation Accuneb® Explained An increased risk of cardiovascular system effects Details Tianeptine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Tianeptine Aspirin Acuprin® An increased risk of bleeding Details Tianeptine Aspirin Rectal Aspirin An increased risk of bleeding Details Tianeptine Bromfenac Ophthalmic Bromday® An increased risk of bleeding Details Tianeptine Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Tianeptine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Tianeptine Clonidine Transdermal Patch Catapres An increased risk of high blood pressure and may counteract the hypotensive effects of cloNIDine Details Tianeptine Diclofenac Ophthalmic Voltaren® Eye Drops An increased risk of bleeding Details Tianeptine Diclofenac Topical (Actinic Keratosis) Pennsaid An increased risk of bleeding Details Tianeptine Diclofenac Topical (Arthritis Pain) Pennsaid® An increased risk of bleeding Details Tianeptine Diclofenac Transdermal Patch Flector An increased risk of bleeding Details Tianeptine Dolasetron Anzemet Increased risk of serotonin syndrome Details Tianeptine Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Tianeptine Etodolac Lodine An increased risk of bleeding Details Tianeptine Fenoprofen Fenopron An increased risk of bleeding Details Tianeptine Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Tianeptine Flurbiprofen Ansaid An increased risk of bleeding Details Tianeptine Flurbiprofen Ophthalmic Ocufen An increased risk of bleeding Details Tianeptine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Tianeptine Granisetron Injection Granisol Increased risk of serotonin syndrome Details Tianeptine Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Tianeptine Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Tianeptine Hydroxychloroquine Plaquenil An increased risk of seizures Details Tianeptine Ibuprofen Addaprin An increased risk of bleeding Details Tianeptine Ketoprofen Actron® An increased risk of bleeding Details Tianeptine Ketorolac Acular An increased risk of bleeding Details Tianeptine Ketorolac Injection Acular An increased risk of bleeding Details Tianeptine Ketorolac Nasal Spray Sprix An increased risk of bleeding Details Tianeptine Ketorolac Ophthalmic Acular An increased risk of bleeding Details Tianeptine Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Tianeptine Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Tianeptine Meclofenamate Meclodium® An increased risk of bleeding Details Tianeptine Mefenamic Acid Ponstel® An increased risk of bleeding Details Tianeptine Meloxicam Alloxate An increased risk of bleeding Details Tianeptine Meloxicam Injection Alloxate An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.