Tilidine

27 interactions 3 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Sertraline Palonosetron Injection Butorphanol Injection Butorphanol Nasal Spray Lacosamide Injection

25 Major 2 Moderate

All (27) Major (25) Moderate (2)

Major

Tilidine Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Tilidine Sertraline Explained An increased risk of serotonin syndrome Details Tilidine Buprenorphine Belbuca Explained An increased risk of serotonin syndrome and an increased risk of respiratory and CNS depression Details Tilidine Butorphanol Injection Butorphic Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Tilidine Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Tilidine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Tilidine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Tilidine Clopidogrel Plavix Reduced efficacy of clopidogrel Details Tilidine Diazepam Nasal Spray Valtoco Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Tilidine Diazepam Rectal Diastat Increased risk of profound sedation, respiratory and CNS depression, coma and death Details Tilidine Esketamine Nasal Spray Spravato Increased risk of sedation Details Tilidine Fentanyl Transdermal Patch Duragesic® Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Tilidine Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Tilidine Granisetron Injection Granisol Increased risk of serotonin syndrome Details Tilidine Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Tilidine Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Tilidine Lacosamide Injection Motpoly An increased risk of CNS depression Details Tilidine Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Tilidine Linezolid Injection Zyvox An increased risk of serotonin syndrome Details Tilidine Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Tilidine Midazolam Nasal Spray Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Tilidine Midazolam Injection Nayzilam Increased risk of hypoventilation, airway obstruction, desaturation, or apnea Details Tilidine Morphine Injection Astramorph® PF Increased risk of respiratory and CNS depression and an increased risk of serotonin syndrome Details Tilidine Nalbuphine Injection Nubain® Increased risk of serotonin syndrome; increased risk of respiratory and CNS depression Details Tilidine Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

Moderate

Tilidine Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details Tilidine Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.