Tirzepatide

Name: Tirzepatide Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

13 interactions

Also sold as: Mounjaro Zepbound

Read the full Tirzepatide drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Estradiol Estradiol Topical Estradiol Transdermal Patch Levonorgestrel Levonorgestrel Intrauterine System

5 Major 8 Moderate

All (13) Major (5) Moderate (8)

Major

Tirzepatide Estradiol Delestrogen Reduced absorption of oral contraceptives Details Tirzepatide Estradiol Topical Divigel Reduced absorption of oral contraceptives Details Tirzepatide Estradiol Transdermal Patch Alora® Reduced absorption of oral contraceptives Details Tirzepatide Levonorgestrel After banger Reduced absorption of oral contraceptives Details Tirzepatide Levonorgestrel Intrauterine System Kyleena Reduced absorption of oral contraceptives Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.