Tirzepatide

Name: Tirzepatide Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

13 interactions

Also sold as: Mounjaro Zepbound

Read the full Tirzepatide drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Estradiol Estradiol Topical Estradiol Transdermal Patch Levonorgestrel Levonorgestrel Intrauterine System

5 Major 8 Moderate

All (13) Major (5) Moderate (8)

Moderate

Tirzepatide Glimepiride Amaryl Increased risk of hypoglycemia Details Tirzepatide Glipizide Glucotrol Increased risk of hypoglycemia Details Tirzepatide Insulin Degludec (Rdna Origin) Injection Ryzodeg® (as a combination product containing Insulin Degludec and Insulin Aspart) Increased risk of hypoglycemia Details Tirzepatide Insulin Detemir (Rdna Origin) Injection Levemir Increased risk of hypoglycemia Details Tirzepatide Insulin Glulisine (Rdna Origin) Injection Apidra Increased risk of hypoglycemia Details Tirzepatide Levothyroxine Ermeza Increased levothyroxine exposure and decreased TSH Details Tirzepatide Liraglutide Injection Saxenda Increased risk of liraglutide-related adverse effects Details Tirzepatide Nateglinide Starlix® Increased risk of hypoglycemia Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.