Tolfenamic Acid

91 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Nasal Spray Ketorolac Injection Ketorolac Ophthalmic Apixaban Pemetrexed Injection
4 Contraindicated 59 Major 28 Moderate
All (91) Contraindicated (4) Major (59) Moderate (28)

Major

Tolfenamic Acid Hydrocortisone Ala-Cort Increased risk of gastrointestinal ulcer or bleeding Details Tolfenamic Acid Hydrocortisone Injection A-Hydrocort® Increased risk of gastrointestinal ulcer or bleeding Details Tolfenamic Acid Ibuprofen Addaprin An increased risk of gastrointestinal toxicity Details Tolfenamic Acid Iloprost Aurlumyn An increased risk of bleeding Details Tolfenamic Acid Ketoprofen Actron® Increased risk of bleeding Details Tolfenamic Acid Lithium Carbonate Lithobid Increased lithium exposure and an increased risk of lithium toxicity Details Tolfenamic Acid Meclofenamate Meclodium® Increased risk of bleeding Details Tolfenamic Acid Mefenamic Acid Ponstel® Increased risk of bleeding Details Tolfenamic Acid Meloxicam Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Tolfenamic Acid Meloxicam Injection Alloxate An increased risk of gastrointestinal toxicity and an increased risk of bleeding Details Tolfenamic Acid Melphalan Alkeran An increased risk of bleeding Details Tolfenamic Acid Melphalan Injection Alkeran An increased risk of bleeding Details Tolfenamic Acid Mesalamine Apriso Increased risk of bleeding Details Tolfenamic Acid Mesalamine Rectal Canasa Increased risk of bleeding Details Tolfenamic Acid Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Tolfenamic Acid Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Tolfenamic Acid Nabumetone Relafen Increased risk of bleeding Details Tolfenamic Acid Naproxen Aleve Increased risk of bleeding Details Tolfenamic Acid Pemetrexed Injection Alimta Increased PEMEtrexed exposure and an increased risk of PEMEtrexed toxicity (myelosuppression, renal toxicity, and gastrointestinal... Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist
Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.