Tolfenamic Acid

91 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketorolac Ketorolac Nasal Spray Ketorolac Injection Ketorolac Ophthalmic Apixaban Pemetrexed Injection
4 Contraindicated 59 Major 28 Moderate
All (91) Contraindicated (4) Major (59) Moderate (28)

Moderate

Tolfenamic Acid Lisinopril Prinivil Explained Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Tolfenamic Acid Atenolol Tenormin Explained Reduced antihypertensive effect Details Tolfenamic Acid Acebutolol Sectral® Reduced antihypertensive effect Details Tolfenamic Acid Benazepril Lotensin Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Tolfenamic Acid Azilsartan Edarbi Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Tolfenamic Acid Betaxolol Betoptic S Reduced antihypertensive effect Details Tolfenamic Acid Betaxolol Ophthalmic Betoptic® Reduced antihypertensive effect Details Tolfenamic Acid Bisoprolol Zebeta® Reduced antihypertensive effect Details Tolfenamic Acid Captopril Capoten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Tolfenamic Acid Desmopressin Nasal Concentraid® Increased risk of water intoxication with hyponatremia Details Tolfenamic Acid Enalapril Epaned Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Tolfenamic Acid Eprosartan Teveten® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Tolfenamic Acid Esmolol Brevibloc Reduced antihypertensive effect Details Tolfenamic Acid Fosinopril Monopril® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Tolfenamic Acid Irbesartan Avapro Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Tolfenamic Acid Labetalol Normodyne® Reduced antihypertensive effect Details Tolfenamic Acid Levobunolol Ophthalmic AKBeta® Reduced antihypertensive effect Details Tolfenamic Acid Levofloxacin Levaquin An increased risk of seizures Details Tolfenamic Acid Levofloxacin Injection Levaquin An increased risk of seizures Details Tolfenamic Acid Losartan Arbli Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Tolfenamic Acid Moexipril Univasc® Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details Tolfenamic Acid Nadolol Corgard Reduced antihypertensive effect Details Tolfenamic Acid Nebivolol Bystolic Reduced antihypertensive effect Details Tolfenamic Acid Ofloxacin Floxin® An increased risk of seizures Details Tolfenamic Acid Ofloxacin Ophthalmic Ocuflox An increased risk of seizures Details Tolfenamic Acid Ofloxacin Otic Floxin® Otic An increased risk of seizures Details Tolfenamic Acid Penbutolol Levatol® Reduced antihypertensive effect Details Tolfenamic Acid Perindopril Aceon Reduced antihypertensive effect and renal dysfunction and/or increased blood pressure Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.