Tolfenamic Acid

91 interactions 5 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Major

Tolfenamic Acid Amitriptyline Elavil Explained An increased risk of bleeding Details Tolfenamic Acid Sertraline Explained An increased risk of bleeding Details Tolfenamic Acid Apixaban Eliquis Explained An increased risk of bleeding Details Tolfenamic Acid Aspirin Acuprin® An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Tolfenamic Acid Aspirin Rectal Aspirin An increased risk of bleeding, decreased renal function, and an increased risk of gastrointestinal adverse events Details Tolfenamic Acid Betrixaban Bevyxxa® An increased risk of bleeding Details Tolfenamic Acid Anagrelide Agrylin An increased risk of bleeding Details Tolfenamic Acid Bromfenac Ophthalmic Bromday® Increased risk of bleeding Details Tolfenamic Acid Budesonide Entocort Increased risk of gastrointestinal ulcer or bleeding Details Tolfenamic Acid Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal ulcer or bleeding Details Tolfenamic Acid Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal ulcer or bleeding Details Tolfenamic Acid Clopidogrel Plavix An increased risk of bleeding Details Tolfenamic Acid Cyclosporine Injection Atopica An increased risk of cycloSPORINE nephrotoxicity Details Tolfenamic Acid Cyclosporine Ophthalmic Cequa An increased risk of cycloSPORINE nephrotoxicity Details Tolfenamic Acid Dabigatran Pradaxa® An increased risk of bleeding Details Tolfenamic Acid Dabigatran Etexilate An increased risk of bleeding Details Tolfenamic Acid Dalteparin Injection Fragmin An increased risk of bleeding Details Tolfenamic Acid Deflazacort Emflaza Increased risk of gastrointestinal ulcer or bleeding Details Tolfenamic Acid Dexamethasone Injection Decadron Increased risk of gastrointestinal ulcer or bleeding Details Tolfenamic Acid Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal ulcer or bleeding Details Tolfenamic Acid Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of bleeding Details Tolfenamic Acid Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of bleeding Details Tolfenamic Acid Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of bleeding Details Tolfenamic Acid Diclofenac Transdermal Patch Flector Increased risk of bleeding Details Tolfenamic Acid Digoxin Cardoxin® Increased digoxin exposure and prolonged half-life of digoxin Details Tolfenamic Acid Dipyridamole Permole® An increased risk of bleeding Details Tolfenamic Acid Edoxaban Savaysa An increased risk of bleeding Details Tolfenamic Acid Emtricitabine Emtriva Increased emtricitabine exposure and an increased risk of emtricitabine-related adverse effects Details Tolfenamic Acid Enoxaparin Lovenox An increased risk of bleeding Details Tolfenamic Acid Enoxaparin Injection Lovenox An increased risk of bleeding Details Tolfenamic Acid Epoprostenol Flolan An increased risk of bleeding Details Tolfenamic Acid Etodolac Lodine Increased risk of bleeding Details Tolfenamic Acid Fenoprofen Fenopron Increased risk of bleeding Details Tolfenamic Acid Flurbiprofen Ansaid Increased risk of bleeding Details Tolfenamic Acid Flurbiprofen Ophthalmic Ocufen Increased risk of bleeding Details Tolfenamic Acid Fondaparinux Arixtra An increased risk of bleeding Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.