Tolterodine

Name: Tolterodine Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

59 interactions 5 explained in plain English

Also sold as: Detrol

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Dasatinib Oxaliplatin Injection Levofloxacin Injection Amisulpride Injection Arsenic Trioxide

1 Contraindicated 50 Major 8 Moderate

All (59) Contraindicated (1) Major (50) Moderate (8)

Moderate

Tolterodine Trospium / Xanomeline Cobenfy Explained An increased risk of anticholinergic adverse reactions (eg, dry mouth, constipation) Details Tolterodine Cyclosporine Injection Atopica Enhanced tolterodine bioavailability in individuals with deficient cytochrome P450 2D6 activity Details Tolterodine Cyclosporine Ophthalmic Cequa Enhanced tolterodine bioavailability in individuals with deficient cytochrome P450 2D6 activity Details Tolterodine Galantamine Razadyne Decreased efficacy of the cholinesterase inhibitor Details Tolterodine Miconazole Buccal Oravig Enhanced tolterodine bioavailability in individuals with deficient cytochrome P450 2D6 activity Details Tolterodine Miconazole Topical Aloe Vesta Antifungal Enhanced tolterodine bioavailability in individuals with deficient cytochrome P450 2D6 activity Details Tolterodine Miconazole Vaginal Lagicam Enhanced tolterodine bioavailability in individuals with deficient cytochrome P450 2D6 activity Details Tolterodine Miconazole Aloe Vesta Antifungal Enhanced tolterodine bioavailability in individuals with deficient cytochrome P450 2D6 activity Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.