Tolterodine

59 interactions 5 explained in plain English

Also sold as: Detrol

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical Dasatinib Oxaliplatin Injection Levofloxacin Injection Amisulpride Injection Arsenic Trioxide

1 Contraindicated 50 Major 8 Moderate

All (59) Contraindicated (1) Major (50) Moderate (8)

Contraindicated

Tolterodine Ketoconazole Topical Extina® Foam Enhanced tolterodine bioavailability in individuals with deficient CYP2D6 activity; increased risk for QT interval prolongation Details

Major

Tolterodine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of paralytic ileus Details Tolterodine Sertraline Explained Increased risk of QT interval prolongation and an increased CYP2D6 substrate exposure Details Tolterodine Buprenorphine Belbuca Explained An increased risk of paralytic ileus and an increased risk of QT interval prolongation Details Tolterodine Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Tolterodine Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Tolterodine Arsenic Trioxide Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Tolterodine Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Tolterodine Arsenic Trioxide Injection Trisenox Increased risk of QT-interval prolongation and torsade de pointes Details Tolterodine Asenapine Transdermal Patch Secuado Increased risk of QT interval prolongation Details Tolterodine Azithromycin AzaSite An increased risk of QT interval prolongation and torsade de pointes Details Tolterodine Abiraterone Abirtega Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse effects Details Tolterodine Anagrelide Agrylin Increased risk of QT interval prolongation Details Tolterodine Bedaquiline Sirturo Increased risk of QT interval prolongation Details Tolterodine Dasatinib Phyrago An increased risk of QT interval prolongation Details Tolterodine Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Tolterodine Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Tolterodine Dofetilide Tikosyn An increased risk of QT interval prolongation Details Tolterodine Encorafenib Braftovi Increased risk of QT interval prolongation Details Tolterodine Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Tolterodine Fentanyl Transdermal Patch Duragesic® Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Tolterodine Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details Tolterodine Fostemsavir Rukobia Increased risk of torsade de pointes Details Tolterodine Glasdegib Daurismo Increased risk of QT interval prolongation Details Tolterodine Glucagon Injection Baqsimi Increased risk of gastrointestinal side effects Details Tolterodine Glucagon Injection / Solution Baqsimi Increased risk of gastrointestinal side effects Details Tolterodine Glucagon Nasal Powder Baqsimi Increased risk of gastrointestinal side effects Details Tolterodine Glycopyrronium Topical Cuvposa® An increased risk of anticholinergic side effects Details Tolterodine Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Tolterodine Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Tolterodine Hydromorphone Injection Dilaudid Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Tolterodine Hydromorphone Rectal available generically Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Tolterodine Hydroxychloroquine Plaquenil An increased risk of seizures and an increased risk of QT interval prolongation Details Tolterodine Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Tolterodine Ivabradine Corlanor Increased risk of QT prolongation Details Tolterodine Lefamulin Xenleta Increased risk of QT interval prolongation Details Tolterodine Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Tolterodine Letermovir Injection Prevymis Increased CYP3A substrate exposure Details Tolterodine Levofloxacin Levaquin Increased risk of QT interval prolongation Details Tolterodine Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.