Topotecan

17 interactions
Also sold as: Hycamtin Hycamtin®
About Topotecan

Topotecan is used to treat small cell lung cancer (a type of cancer that begins in the lungs) that was successfully treated with a different chemotherapy medication but has returned no sooner than 45 days after the last dose of the first chemotherapy medication was taken. Topotecan is in a class of medications called t… Read the full Topotecan drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lenacapavir Injection Fostemsavir Ketoconazole Topical Leflunomide Leniolisib Midostaurin
16 Major 1 Moderate
All (17) Major (16) Moderate (1)

Moderate

Topotecan Encorafenib Braftovi Increased BCRP substrate exposure and an increased risk of BCRP substrate-related toxicities Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.