Drug Interaction Report

Trabectedin and Encorafenib: Interaction Details

A pharmacist-reviewed analysis of the Trabectedin and Encorafenib interaction: the documented clinical effects, severity rating, onset, mechanism, and management considerations, with cited references throughout.

AI-assisted, pharmacist-reviewed · Source data updated Aug 8, 2026 · Sources: FDA labeling, DDInter 2.0, cited literature

Encorafenib

Braftovi Braftovi®
+

Trabectedin

Yondelis
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by
Dr. Brian Staiger, PharmD, BCPS
Updated Aug 8, 2026
Editorial policy · Data sources
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Interaction severity
Major
Potentially serious — often needs a change or close monitoring.
How we grade severity & evidence

Severity levels

  • Contraindicated: These should generally not be used together.
  • Major: Potentially serious — often needs a change or close monitoring.
  • Moderate: Can be significant — usually manageable with monitoring.
  • Minor: Usually limited clinical impact.

Evidence grades

  • Established: Well documented — supported by controlled studies or strong clinical data.
  • Probable: Good supporting evidence, though not definitively proven.
  • Suspected: Some evidence suggests this interaction, but it is not well established.
  • Possible: Limited or conflicting evidence; the interaction may occur.
  • Theoretical: Predicted from the drugs' pharmacology; not yet confirmed in people.

Ratings come from the documented interaction literature and are reviewed by a pharmacist. They describe the documented risk of the combination, not what will necessarily happen to you — your dose, timing, and health picture all matter.

Worried about symptoms right now? Contact your pharmacist or prescriber, or call Poison Control at 1-800-222-1222 (US). Call 911 for an emergency.
Onset
unspecified
Evidence
theoretical
Severity
Major

What happens

Reduced trabectedin exposure

Interaction Deep Dive

Drug interaction studies demonstrated that coadministration of multiple doses of rifAMPin (a strong CYP3A inducer) and single-dose trabectedin resulted in a decrease in trabectedin AUC and Cmax. Therefore, avoid concomitant use of trabectedin and a strong CYP3A inducer as this may reduce trabectedin exposure12.

Why it happens (mechanism)

Induction of CYP3A-mediated metabolism of trabectedin

Literature reports

1 report — tap to read

a) Coadministration of trabectedin 1.3 mg/m(2) single-dose on day 6 with multiple doses of rifAMPin (600 mg/day for 6 days) resulted in a 31% decrease in trabectedin AUC and a 21% decrease in trabectedin Cmax compared with when trabectedin was given alone 12.

Common questions

Can I take Trabectedin and Encorafenib together?

Reduced trabectedin exposure Always confirm with your pharmacist or prescriber before making any change.

How serious is the Trabectedin and Encorafenib interaction?

It is rated major. Potentially serious — often needs a change or close monitoring.

How quickly could this interaction happen?

The documented onset is "unspecified". The timing of this interaction is not well characterized.

How strong is the evidence for this interaction?

The evidence is graded "theoretical". Predicted from the drugs' pharmacology; not yet confirmed in people.

Questions for your pharmacist

  • Does my dose of Trabectedin or Encorafenib need adjusting while I take them together?
  • What symptoms should prompt me to call you or my prescriber right away?
  • Does the timing of my doses matter for this combination?
  • Is there a safer alternative to one of these medications for me?

References (2)

  1. Product Information: YONDELIS(R) intravenous injection powder, trabectedin intravenous injection powder. Janssen Products, LP (per FDA), Horsham, PA, 2015. DailyMed
  2. Product Information: EVDI intravenous injection, trabectedin intravenous injection. Apotex Corp, Weston, FL, 2026. DailyMed
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Encorafenib

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All Encorafenib interactions (468) Encorafenib drug information
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Trabectedin

Keep reading about Trabectedin

All Trabectedin interactions (4)
Also serious with: Abametapir Ketoconazole Topical Letermovir Injection
Beyond drug–drug

These medications also interact with supplements

Prescription drugs aren't the whole picture — herbal and dietary supplements can interact with them too. From the evidence-graded Natural Medicines database:

Encorafenib + Activated Charcoal American Hellebore Arsenic Cesium Ephedra Grapefruit Sida Cordifolia St. John's Wort + 143 more
Trabectedin + Beer Grapefruit Siberian Cocklebur St. John's Wort Wine Acacia Rigidula Acerola Adrafinil + 148 more

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This information is for education, not a substitute for professional medical advice. Do not start, stop, or change any medication without talking to your pharmacist or prescriber.