Treosulfan

36 interactions 3 explained in plain English

Also sold as: Grafapex

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lumateperone Olaparib Abemaciclib Everolimus Mitapivat Axitinib

34 Major 2 Moderate

All (36) Major (34) Moderate (2)

Major

Treosulfan Clindamycin ANTIROBE Explained Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Colchicine Colcrys Explained Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Abemaciclib Verzenio Explained Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Acalabrutinib Calquence Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Amlodipine Amvaz® Increased amLODIPine exposure and an increased risk of hypotension and edema Details Treosulfan Axitinib Inlyta Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Bosutinib Bosulif Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Brexpiprazole Rexulti Increased brexpiprazole exposure Details Treosulfan Brigatinib Alunbrig Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Clindamycin Injection ANTIROBE Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Clindamycin Topical C/T/S® Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Clindamycin Vaginal Cleocin Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Cobimetinib Cotellic Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Cyclosporine Injection Atopica Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Cyclosporine Ophthalmic Cequa Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Dasatinib Phyrago Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Dihydroergotamine Injection DHE-45® Injection Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Dihydroergotamine Nasal Spray Migranal Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Docetaxel Beizray Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Docetaxel Injection Beizray Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Dofetilide Tikosyn Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Entrectinib Rozlytrek Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Everolimus Afinitor Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Fentanyl Transdermal Patch Duragesic® Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Finerenone Kerendia Increased finerenone exposure and an increased risk of finerenone-related adverse effects Details Treosulfan Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse reactions Details Treosulfan Lumateperone Caplyta Increased lumateperone exposure and increased risk of lumateperone-related adverse reactions Details Treosulfan Lurbinectedin Injection Zepzelca Increased lurbinectedin exposure and an increased risk of lurbinectedin-related adverse reactions Details Treosulfan Methylergonovine Methergine Increased methylergonovine exposure and an increased risk of vasospasm, cerebral ischemia and/or ischemia of extremities Details Treosulfan Midostaurin Rydapt Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Mitapivat Aqvesme Increased mitapivat exposure Details Treosulfan Neratinib Nerlynx Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details Treosulfan Nifedipine Adalat® Increased NIFEdipine exposure Details Treosulfan Olaparib Lynparza Increased CYP3A4 substrate exposure and an increased risk of CYP3A4 substrate-related adverse and serious life-threatening toxicit... Details

Moderate

Treosulfan Hydrocortisone Ala-Cort Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details Treosulfan Hydrocortisone Injection A-Hydrocort® Increased hydrocortisone exposure and an increased risk of hydrocortisone-related adverse reactions Details

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