Triamterene

Name: Triamterene Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

68 interactions 4 explained in plain English

Also sold as: Dyrenium

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Dofetilide Methotrexate Injection Linagliptin Hydromorphone Rectal Perindopril Canagliflozin

1 Contraindicated 61 Major 6 Moderate

All (68) Contraindicated (1) Major (61) Moderate (6)

Moderate

Triamterene Aliskiren Tekturna Hyperkalemia Details Triamterene Asenapine Transdermal Patch Secuado An increased risk of hypotension Details Triamterene Irbesartan Avapro Increased risk of hyperkalemia Details Triamterene Lithium Carbonate Lithobid Increased lithium concentrations and lithium toxicity (weakness, tremor, excessive thirst, confusion) Details Triamterene Losartan Arbli Increased risk of hyperkalemia Details Triamterene Metformin Fortamet® An increased risk of hyperglycemia and potential loss of glycemic control Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.