Trifluperidol

19 interactions 2 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lacosamide Injection Hydromorphone Rectal Butorphanol Injection Butorphanol Nasal Spray Nalbuphine Injection Cetirizine Ophthalmic
18 Major 1 Moderate
All (19) Major (18) Moderate (1)

Major

Trifluperidol Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Trifluperidol Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Trifluperidol Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Trifluperidol Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Trifluperidol Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Trifluperidol Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Trifluperidol Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Trifluperidol Diazepam Rectal Diastat Increased risk of CNS depression Details Trifluperidol Esketamine Nasal Spray Spravato Increased risk of sedation Details Trifluperidol Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Trifluperidol Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Trifluperidol Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Trifluperidol Lacosamide Injection Motpoly An increased risk of CNS depression Details Trifluperidol Levodopa Oral Inhalation Inbrija An increased risk of CNS depression Details Trifluperidol Metoclopramide Injection Gimoti Increased risk of CNS depression Details Trifluperidol Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Trifluperidol Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Trifluperidol Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details

Moderate

Trifluperidol Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.