Trimeprazine

25 interactions 2 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lacosamide Injection Hydromorphone Rectal Butorphanol Injection Butorphanol Nasal Spray Octreotide Injection Cetirizine Ophthalmic

24 Major 1 Moderate

All (25) Major (24) Moderate (1)

Major

Trimeprazine Acetaminophen And Codeine Capital® & Codeine Explained An increased risk of respiratory and CNS depression Details Trimeprazine Buprenorphine Belbuca Explained An increased risk of respiratory depression and CNS depression Details Trimeprazine Butorphanol Injection Butorphic Increased risk of respiratory and CNS depression Details Trimeprazine Butorphanol Nasal Spray Stadol® NS Increased risk of respiratory and CNS depression Details Trimeprazine Cetirizine Injection Aller-Tec Increased risk of CNS depression Details Trimeprazine Cetirizine Ophthalmic Zerviate Increased risk of CNS depression Details Trimeprazine Diazepam Nasal Spray Valtoco Increased risk of CNS depression Details Trimeprazine Diazepam Rectal Diastat Increased risk of CNS depression Details Trimeprazine Esketamine Nasal Spray Spravato Increased risk of sedation Details Trimeprazine Fentanyl Transdermal Patch Duragesic® Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Trimeprazine Gatifloxacin Ophthalmic Zymar® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Trimeprazine Hydromorphone Injection Dilaudid Increased risk of respiratory and CNS depression Details Trimeprazine Hydromorphone Rectal available generically Increased risk of respiratory and CNS depression Details Trimeprazine Hydroxychloroquine Plaquenil An increased risk of seizures Details Trimeprazine Isradipine DynaCirc® An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Trimeprazine Lacosamide Injection Motpoly An increased risk of CNS depression Details Trimeprazine Levodopa Oral Inhalation Inbrija Reduce efficacy of levodopa (foslevodopa), an increased risk of exacerbating psychosis [or symptoms of Parkinson's disease: delusi... Details Trimeprazine Lithium Carbonate Lithobid Weakness, dyskinesias, increased extrapyramidal symptoms, encephalopathy, and brain damage Details Trimeprazine Metoclopramide Injection Gimoti Increased risk of CNS depression Details Trimeprazine Metoclopramide Nasal Spray Gimoti Increased risk of CNS depression Details Trimeprazine Morphine Injection Astramorph® PF Increased risk of profound sedation, respiratory depression, hypotension, coma and death Details Trimeprazine Nalbuphine Injection Nubain® Increased risk of respiratory and CNS depression Details Trimeprazine Octreotide Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details Trimeprazine Octreotide Injection Bynfezia An increased risk of cardiotoxicity (QT prolongation, torsades de pointes, cardiac arrest) Details

Moderate

Trimeprazine Clonidine Transdermal Patch Catapres An increased risk of sedation and somnolence Details

Check another drug

Still have questions about this combination?

Every question gets a real answer from a licensed pharmacist — free, and usually within a day.

Ask the pharmacist

Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.