Trimetrexate

9 interactions
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 8, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Ketoconazole Topical
1 Major 8 Moderate
All (9) Major (1) Moderate (8)

Major

Trimetrexate Ketoconazole Topical Extina® Foam Increased trimetrexate exposure and an increased trimetrexate-related adverse reactions Details

Moderate

Trimetrexate Clotrimazole Aardora Anti-Fungal Maximum Strength Increased trimetrexate toxicity (bone marrow suppression, renal and hepatic dysfunction, and gastrointestinal ulceration) Details Trimetrexate Clotrimazole Lozenge Mycelex® Increased trimetrexate toxicity (bone marrow suppression, renal and hepatic dysfunction, and gastrointestinal ulceration) Details Trimetrexate Clotrimazole Topical Cruex Antifungal Increased trimetrexate toxicity (bone marrow suppression, renal and hepatic dysfunction, and gastrointestinal ulceration) Details Trimetrexate Clotrimazole Vaginal Gyne-Lotrimin 3® Cream Increased trimetrexate toxicity (bone marrow suppression, renal and hepatic dysfunction, and gastrointestinal ulceration) Details Trimetrexate Miconazole Buccal Oravig Increased trimetrexate toxicity (bone marrow suppression, renal & hepatic dysfunction, and gastrointestinal ulceration) Details Trimetrexate Miconazole Topical Aloe Vesta Antifungal Increased trimetrexate toxicity (bone marrow suppression, renal & hepatic dysfunction, and gastrointestinal ulceration) Details Trimetrexate Miconazole Vaginal Lagicam Increased trimetrexate toxicity (bone marrow suppression, renal & hepatic dysfunction, and gastrointestinal ulceration) Details Trimetrexate Miconazole Aloe Vesta Antifungal Increased trimetrexate toxicity (bone marrow suppression, renal & hepatic dysfunction, and gastrointestinal ulceration) Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.