Trospium / Xanomeline

122 interactions 122 explained in plain English 59 cited references

Also sold as: Cobenfy

Read the full Trospium / Xanomeline drug information page

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Potassium Citrate Potassium Chloride Alfentanil Amantadine Amifampridine Benzhydrocodone

2 Contraindicated 40 Major 79 Moderate 1 Minor

All (122) Contraindicated (2) Major (40) Moderate (79) Minor (1)

Contraindicated

Trospium / Xanomeline Potassium Chloride K-Tab Explained Increased risk of gastrointestinal irritation Details Trospium / Xanomeline Potassium Citrate Urocit-K Explained Increased risk of gastrointestinal irritation Details

Major

Trospium / Xanomeline Alfentanil Explained An increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Trospium / Xanomeline Amantadine Explained Potentiation of anticholinergic effects Details Trospium / Xanomeline Amifampridine Explained Increased risk of seizures Details Trospium / Xanomeline Benzhydrocodone Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Trospium / Xanomeline Buprenorphine Belbuca Explained An increased risk of paralytic ileus Details Trospium / Xanomeline Clomipramine Anafranil Explained An increased risk of anticholinergic effects and an increased risk of seizures Details Trospium / Xanomeline Clozapine Clozaril Explained Increased risk of anticholinergic toxicity and gastrointestinal adverse reactions Details Trospium / Xanomeline Codeine Tuzistra XR® (as a combination product containing Chlorpheniramine, Codeine) Explained An increased risk of paralytic ileus Details Trospium / Xanomeline Cyclobenzaprine Amrix Explained An increased risk of atropine-like adverse reactions Details Trospium / Xanomeline Dihydrocodeine Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Trospium / Xanomeline Donepezil Adlarity Explained Reduced seizure threshold Details Trospium / Xanomeline Fentanyl Explained Increased risk of urinary retention and/or severe constipation, which may lead to paralytic ileus Details Trospium / Xanomeline Glucagon Explained Increased risk of gastrointestinal side effects Details Trospium / Xanomeline Glycopyrrolate Cuvposa Explained An increased risk of anticholinergic side effects Details Trospium / Xanomeline Glycopyrronium Tosylate Explained An increased risk of anticholinergic side effects Details Trospium / Xanomeline Hydrocodone Hysingla Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Trospium / Xanomeline Hydromorphone Dilaudid Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Trospium / Xanomeline Hydroxychloroquine Plaquenil Explained An increased risk of seizures Details Trospium / Xanomeline Letibotulinumtoxina-Wlbg Letybo Explained Increased neuromuscular weakness and heightened systemic anticholinergic effects Details Trospium / Xanomeline Lumefantrine Explained Increased CYP2D6 substrate exposure and an increased risk of CYP2D6 substrate-related adverse reactions Details Trospium / Xanomeline Meperidine Demerol Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Trospium / Xanomeline Methacholine Explained Inhibition of the airway response to methacholine Details Trospium / Xanomeline Methadone Diskets Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Trospium / Xanomeline Morphine Explained Increased morphine exposure, increased trospium exposure and an increased risk of urinary retention, constipation and paralytic il... Details Trospium / Xanomeline Morphine Sulfate Liposome Explained Increased morphine exposure, increased trospium exposure and an increased risk of urinary retention, constipation and paralytic il... Details Trospium / Xanomeline Olanzapine Explained Increased risk of severe gastrointestinal adverse reactions Details Trospium / Xanomeline Oliceridine Olinvyk Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Trospium / Xanomeline Oxycodone Oxaydo Explained An increased risk of paralytic ileus Details Trospium / Xanomeline Oxymorphone Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Trospium / Xanomeline Promethazine Phenadoz Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Trospium / Xanomeline Ranolazine Aspruzyo Explained Increased CYP2D6 substrates exposure Details Trospium / Xanomeline Revefenacin Yupelri Explained Increased risk of anticholinergic side effects Details Trospium / Xanomeline Scopolamine Pamine Explained Increased or potentiated scopolamine effects, an increased risk of CNS adverse reactions and an increased risk of intestinal obstr... Details Trospium / Xanomeline Secretin Human Chirhostim Explained False positive stimulation test results with secretin human Details Trospium / Xanomeline Sertraline Explained Increased CYP2D6 substrate exposure Details Trospium / Xanomeline Sofpironium Explained An increased risk of hyperpyrexia and heat stroke due to decreased sweating Details Trospium / Xanomeline Sufentanil Dsuvia Explained Increased risk of urinary retention and/or severe constipation leading to paralytic ileus Details Trospium / Xanomeline Tapentadol Nucynta Explained An increased risk of paralytic ileus Details

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