Tryptophan

18 interactions 4 explained in plain English
Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Linezolid Injection Lithium Carbonate Granisetron Injection Hydromorphone Injection Hydromorphone Rectal Nalbuphine Injection
1 Contraindicated 17 Major
All (18) Contraindicated (1) Major (17)

Contraindicated

Tryptophan Linezolid Injection Zyvox An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details

Major

Tryptophan Acetaminophen And Codeine Capital® & Codeine Explained Increased risk of serotonin syndrome Details Tryptophan Amitriptyline Elavil Explained Increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Tryptophan Sertraline Explained An increased risk of serotonin syndrome (hypertension, hyperthermia, myoclonus, mental status changes) Details Tryptophan Buprenorphine Belbuca Explained An increased risk of serotonin syndrome Details Tryptophan Butorphanol Injection Butorphic Increased risk of serotonin syndrome Details Tryptophan Butorphanol Nasal Spray Stadol® NS Increased risk of serotonin syndrome Details Tryptophan Dolasetron Anzemet Increased risk of serotonin syndrome Details Tryptophan Dolasetron Injection Anzemet Increased risk of serotonin syndrome Details Tryptophan Fentanyl Transdermal Patch Duragesic® Increased risk of serotonin syndrome Details Tryptophan Granisetron Transdermal Patch Sancuso Increased risk of serotonin syndrome Details Tryptophan Granisetron Injection Granisol Increased risk of serotonin syndrome Details Tryptophan Hydromorphone Injection Dilaudid Increased risk of serotonin syndrome Details Tryptophan Hydromorphone Rectal available generically Increased risk of serotonin syndrome Details Tryptophan Lithium Carbonate Lithobid Increased risk of serotonin syndrome Details Tryptophan Morphine Injection Astramorph® PF Increased risk of serotonin syndrome Details Tryptophan Nalbuphine Injection Nubain® Increased risk of serotonin syndrome Details Tryptophan Palonosetron Injection Aloxi® An increased risk of serotonin syndrome Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.