Upadacitinib

71 interactions 3 explained in plain English

Also sold as: Rinvoq Rinvoq®

About Upadacitinib

Upadacitinib is used alone or with other medications to treat rheumatoid arthritis (condition in which the body attacks its own joints causing pain, swelling, and loss of function) in people who are unable to take or have not responded well to one or more tumor necrosis factor (TNF) inhibitor medication(s). It is also… Read the full Upadacitinib drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Lumateperone Desonide Diflorasone Topical Fludrocortisone Acetate Ciclesonide Nasal Spray Nifedipine

70 Major 1 Moderate

All (71) Major (70) Moderate (1)

Major

Upadacitinib Abametapir Explained Increased exposure of CYP3A4 substrate Details Upadacitinib Abatacept Injection Orencia An increased risk of infection Details Upadacitinib Aspirin Acuprin® Increased risk of gastrointestinal perforations Details Upadacitinib Aspirin Rectal Aspirin Increased risk of gastrointestinal perforations Details Upadacitinib Atogepant Qulipta Reduced atogepant exposure Details Upadacitinib Abatacept Orencia Explained An increased risk of infection Details Upadacitinib Cariprazine Vraylar Explained Effects on the cariprazine exposure has not been evaluated and the net effect is unclear Details Upadacitinib Amlodipine Amvaz® Reduced amLODIPine exposure Details Upadacitinib Baricitinib Olumiant An increased risk of infection Details Upadacitinib Beclomethasone Nasal Spray Beconase Increased risk of gastrointestinal perforations Details Upadacitinib Beclomethasone Oral Inhalation Beclovent® Increased risk of gastrointestinal perforations Details Upadacitinib Bromfenac Ophthalmic Bromday® Increased risk of gastrointestinal perforations Details Upadacitinib Budesonide Entocort Increased risk of gastrointestinal perforations Details Upadacitinib Budesonide Nasal Spray Rhinocort Increased risk of gastrointestinal perforations Details Upadacitinib Budesonide Oral Inhalation Pulmicort Increased risk of gastrointestinal perforations Details Upadacitinib Ciclesonide Nasal Spray Omnaris Increased risk of gastrointestinal perforations Details Upadacitinib Ciclesonide Oral Inhalation Alvesco Increased risk of gastrointestinal perforations Details Upadacitinib Clobetasol Byqlovi Increased risk of gastrointestinal perforations Details Upadacitinib Clobetasol Topical Clobex® Increased risk of gastrointestinal perforations Details Upadacitinib Deflazacort Emflaza Increased risk of gastrointestinal perforations Details Upadacitinib Desonide Desowen Increased risk of gastrointestinal perforations Details Upadacitinib Desonide Topical Desonate® Increased risk of gastrointestinal perforations Details Upadacitinib Desoximetasone Topicort Increased risk of gastrointestinal perforations Details Upadacitinib Desoximetasone Topical Topicort Increased risk of gastrointestinal perforations Details Upadacitinib Dexamethasone Injection Decadron Increased risk of gastrointestinal perforations Details Upadacitinib Dexamethasone Ophthalmic Dexacidin® (as a combination product containing Dexamethasone, Neomycin, Polymyxin B) Increased risk of gastrointestinal perforations Details Upadacitinib Diclofenac Ophthalmic Voltaren® Eye Drops Increased risk of gastrointestinal perforations Details Upadacitinib Diclofenac Topical (Actinic Keratosis) Pennsaid Increased risk of gastrointestinal perforations Details Upadacitinib Diclofenac Topical (Arthritis Pain) Pennsaid® Increased risk of gastrointestinal perforations Details Upadacitinib Diclofenac Transdermal Patch Flector Increased risk of gastrointestinal perforations Details Upadacitinib Diflorasone Topical Apexicon Increased risk of gastrointestinal perforations Details Upadacitinib Difluprednate Ophthalmic Durezol Increased risk of gastrointestinal perforations Details Upadacitinib Etodolac Lodine Increased risk of gastrointestinal perforations Details Upadacitinib Fenoprofen Fenopron Increased risk of gastrointestinal perforations Details Upadacitinib Fludrocortisone Acetate Florinef® Increased risk of gastrointestinal perforations Details Upadacitinib Flunisolide Nasal Spray Nasalide® Increased risk of gastrointestinal perforations Details Upadacitinib Flunisolide Oral Inhalation AeroBid® Inhaler System Increased risk of gastrointestinal perforations Details Upadacitinib Fluocinolone Capex Increased risk of gastrointestinal perforations Details Upadacitinib Fluocinolone Topical Capex® Shampoo Increased risk of gastrointestinal perforations Details Upadacitinib Fluocinonide Vanos Increased risk of gastrointestinal perforations Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.