Vanzacaftor

Name: Vanzacaftor Drug Interactions
Creator: Dr. Brian Staiger, PharmD, BCPS

9 interactions 1 explained in plain English

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jul 4, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Relugolix Ketoconazole Topical Lefamulin Lenacapavir Injection Lenacapavir Oral Letermovir Injection

9 Major

All (9) Major (9)

Major

Vanzacaftor Relugolix Orgovyx Explained Increased relugolix exposure Details Vanzacaftor Ketoconazole Topical Extina® Foam Increased vanzacaftor exposure and an increased risk of vanzacaftor-related adverse reactions Details Vanzacaftor Lefamulin Xenleta Increased vanzacaftor exposure and an increased risk of vanzacaftor-related adverse reactions Details Vanzacaftor Lenacapavir Injection Sunlenca Increased vanzacaftor exposure and an increased risk of vanzacaftor-related adverse reactions Details Vanzacaftor Lenacapavir Oral Sunlenca Increased vanzacaftor exposure and an increased risk of vanzacaftor-related adverse reactions Details Vanzacaftor Letermovir Injection Prevymis Increased vanzacaftor exposure and an increased risk of vanzacaftor-related adverse reactions Details Vanzacaftor Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details Vanzacaftor Mitapivat Aqvesme Reduced vanzacaftor exposure and reduced efficacy of vanzacaftor Details Vanzacaftor Nafcillin Injection Unipen® Injection Reduced vanzacaftor exposure and reduced efficacy of vanzacaftor Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.