Vardenafil

78 interactions 5 explained in plain English
Also sold as: Levitra Levitra® Staxyn Staxyn®
About Vardenafil

Vardenafil is a phosphodiesterase inhibitor used to treat erectile dysfunction in men. Read the full Vardenafil drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Nitroglycerin Nitroglycerin Topical Nitroglycerin Sublingual Nitroglycerin Spray Isosorbide Dinitrate Ketoconazole Topical
8 Contraindicated 65 Major 5 Moderate
All (78) Contraindicated (8) Major (65) Moderate (5)

Major

Vardenafil Inotuzumab Ozogamicin Injection Besponsa Increased risk of QT interval prolongation Details Vardenafil Ivabradine Corlanor Increased risk of QT prolongation Details Vardenafil Lenacapavir Injection Sunlenca Increased sensitive CYP3A substrate exposure Details Vardenafil Lenacapavir Oral Sunlenca Increased sensitive CYP3A substrate exposure Details Vardenafil Lenvatinib Lenvima Increased risk of QT-interval prolongation Details Vardenafil Levofloxacin Levaquin Increased risk of QT interval prolongation Details Vardenafil Levofloxacin Injection Levaquin Increased risk of QT interval prolongation Details Vardenafil Loperamide Diamode An increased risk of QT interval prolongation, which may increase risk of cardiotoxicity (torsade de pointes, cardiac arrest) Details Vardenafil Mefloquine Lariam® An increased risk of QT interval prolongation Details Vardenafil Metronidazole Flagyl An increased risk of QT interval prolongation Details Vardenafil Metronidazole Injection Flagyl An increased risk of QT interval prolongation Details Vardenafil Metronidazole Topical MetroCream® An increased risk of QT interval prolongation Details Vardenafil Metronidazole Vaginal MetroGel® Vaginal An increased risk of QT interval prolongation Details Vardenafil Mitapivat Aqvesme Reduced CYP3A substrate exposure Details Vardenafil Moxifloxacin Avelox Increased risk of QT interval prolongation Details Vardenafil Moxifloxacin Injection Avelox Increased risk of QT interval prolongation Details Vardenafil Moxifloxacin Ophthalmic Moxeza® Increased risk of QT interval prolongation Details Vardenafil Octreotide Bynfezia An increased risk of QT interval prolongation Details Vardenafil Octreotide Injection Bynfezia An increased risk of QT interval prolongation Details Vardenafil Ofloxacin Floxin® An increased risk of QT interval prolongation Details Vardenafil Ofloxacin Ophthalmic Ocuflox An increased risk of QT interval prolongation Details Vardenafil Ofloxacin Otic Floxin® Otic An increased risk of QT interval prolongation Details Vardenafil Olodaterol Oral Inhalation Striverdi An increased risk of QT interval prolongation and an increased risk of ventricular arrhythmias Details Vardenafil Olutasidenib Rezlidhia Reduced sensitive CYP3A substrate exposure Details Vardenafil Oxaliplatin Injection Eloxatin® Increased risk of QT-interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.