Vardenafil

78 interactions 5 explained in plain English
Also sold as: Levitra Levitra® Staxyn Staxyn®
About Vardenafil

Vardenafil is a phosphodiesterase inhibitor used to treat erectile dysfunction in men. Read the full Vardenafil drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Jun 30, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Nitroglycerin Nitroglycerin Topical Nitroglycerin Sublingual Nitroglycerin Spray Isosorbide Dinitrate Ketoconazole Topical
8 Contraindicated 65 Major 5 Moderate
All (78) Contraindicated (8) Major (65) Moderate (5)

Major

Vardenafil Amitriptyline Elavil Explained An increased risk of QT interval prolongation Details Vardenafil Sertraline Explained An increased risk of QT interval prolongation Details Vardenafil Buprenorphine Belbuca Explained An increased risk of QT interval prolongation Details Vardenafil Relugolix Orgovyx Explained Increased risk of QT interval prolongation Details Vardenafil Amisulpride Injection Barhemsys Increased risk of serious ventricular arrhythmias such as torsades de pointes Details Vardenafil Arsenic Trioxide Trisenox An increased risk of QT interval prolongation Details Vardenafil Aripiprazole Injection Abilify An increased risk of QT interval prolongation Details Vardenafil Arsenic Trioxide Injection Trisenox An increased risk of QT interval prolongation Details Vardenafil Asenapine Transdermal Patch Secuado An increased risk of QT interval prolongation Details Vardenafil Azithromycin AzaSite An increased risk of QT interval prolongation Details Vardenafil Alfuzosin UroXatral Potentiation of hypotensive effects and an increased risk of QT interval prolongation Details Vardenafil Anagrelide Agrylin Increased risk of QT interval prolongation Details Vardenafil Bedaquiline Sirturo An increased risk of QT interval prolongation Details Vardenafil Chloroquine Aralen® An increased risk of QT interval prolongation Details Vardenafil Dasatinib Phyrago An increased risk of QT interval prolongation Details Vardenafil Degarelix Injection Firmagon Increased risk of QT interval prolongation Details Vardenafil Deutetrabenazine Austedo An increased risk of QT interval prolongation Details Vardenafil Disopyramide Norpace An increased risk of QT interval prolongation Details Vardenafil Dofetilide Tikosyn An increased risk of QT interval prolongation Details Vardenafil Dolasetron Anzemet An increased risk of QT interval prolongation Details Vardenafil Dolasetron Injection Anzemet An increased risk of QT interval prolongation Details Vardenafil Doxazosin Cardura Potentiation of hypotensive effects Details Vardenafil Encorafenib Braftovi Reduced CYP3A4 substrate exposure, reduced efficacy of CYP3A4 substrate and an increased risk of QT interval prolongation Details Vardenafil Entrectinib Rozlytrek An increased risk of QT interval prolongation Details Vardenafil Eribulin Injection Halaven An increased risk of QT interval prolongation Details Vardenafil Famotidine Calmicid An increased risk of QT interval prolongation Details Vardenafil Famotidine Injection Calmicid An increased risk of QT interval prolongation Details Vardenafil Felbamate Felbatol An increased risk of QT interval prolongation Details Vardenafil Flecainide Tambocor® An increased risk of QT interval prolongation Details Vardenafil Foscarnet Injection Foscavir Increased risk of QT interval prolongation Details Vardenafil Fostemsavir Rukobia Increased risk of torsade de pointes Details Vardenafil Galantamine Razadyne An increased risk of QT interval prolongation Details Vardenafil Gatifloxacin Ophthalmic Zymar® An increased risk of QT interval prolongation Details Vardenafil Gemifloxacin Factive An increased risk of QT interval prolongation Details Vardenafil Glasdegib Daurismo Increased risk of QT interval prolongation Details Vardenafil Goserelin Implant Zoladex Increased risk of QT interval prolongation Details Vardenafil Granisetron Transdermal Patch Sancuso An increased risk of QT interval prolongation Details Vardenafil Granisetron Injection Granisol An increased risk of QT interval prolongation Details Vardenafil Histrelin Implant Supprelin Increased risk of QT interval prolongation Details Vardenafil Hydroxychloroquine Plaquenil Increased risk of QT interval prolongation Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.